3D-SC人工皮肤材料体内降解实验研究  

Research on degradation of 3D-SC artificial skin material in vivo

作　　者：陈敏[1] 廖隆理[1] 但卫华[1] 李志强[1] 王坤余[1] 曾睿[2] 陈驰[1] 但年华[1] 

机构地区：[1]四川大学皮革化工与工程教育部重点实验室,四川成都610065 [2]四川大学生物医学工程技术研究中心

出　　处：《生物医学工程与临床》2005年第1期1-3,共3页Biomedical Engineering and Clinical Medicine

基　　金：国家高技术研究发展计划项目(2001AA326090);四川省科技攻关项目(02ZX028-042)

摘　　要：目的测试3D-SC人工皮肤材料在动物体内的降解性。方法将一定大小的材料真空干燥后植入动物背部皮下,分阶段取出植入材料,观察材料及周围组织情况,将取出的材料真空干燥至恒重。计算材料的质量损失百分率。结果未见材料周围组织异常,第3天材料质量增加3.39%,以后逐渐降低,第7、14、28、42、56、70、84、98天材料质量损失百分率分别为2.06%、7.58%、14.31%、26.83%、37.45%、38.08%、85.45%、87.26%。结论3D-SC人工皮肤材料是一种具有优良生物降解性能的材料,降解产物无毒性,在体内降解过程中表现出较好的生物相容性。70d内降解相对较慢,70d后降解速度加快,降解产物被动物吸收。Objective To test the degradation of 3D-SC artificial skin material in vivo. Methods A certain sized material was firstly vacuum-dried,and then implanted into animal back subcutaneously. The collected the implant and its surrounding tissues were observed at different time after implantation,then the removed implants were vacuum-dried to a constant-weight, then the mass-decreasing percentage was calculated. Results Nothing abnormal was found in material surrounding tissues.The mass of material increased 3.39 % after 3 days,and then decreased gradually. The percentages of material mass decreased after 7,14,28,42,56,70,84,98 days were 2.06 %,7.58 %,14.32 %,26.83 %,37.45 %,38.08 %,85.45 %,87.26 %,respectively. Conclusion The 3D-SC artificial skin material is good at biodegradability,biocompatibility and of no toxicity in degrading products. It degrades rather slow with in 70 days after implantation,afterward the degradation rate increases. The degraded products are absorbed by the animal recipient.

关 键 词：人工皮肤 体内降解 取出 周围组织 实验研究 降解产物 动物体内 百分率 结论 大小 

分 类 号：R318.1[医药卫生—生物医学工程]