GADAb、ICA和IAA联合检测与LADA早期诊断  

Significance of GADAb,ICA and IAA measurements for the early diagnosis of LADA

作　　者：范爱红[1] 徐卓华[1] 陈燕[1] 叶山东[1] 

机构地区：[1]安徽省立医院内分泌实验室,合肥230001

出　　处：《安徽医学》2005年第1期18-19,共2页Anhui Medical Journal

摘　　要：目的　联合检测GADAb、ICA和IAA。早期诊断成人隐匿性自身免疫性糖尿病 (LADA ) ,以保护胰岛 β细胞功能。方法　初次临床诊断的 2型糖尿病 (2 -DM ) 13 0例 ,正常对照组 5 0例分别用酶免法测定谷氨酸脱羧酶抗体(GADA)、胰岛细胞抗体 (ICA) ,用放免法测定胰岛素自身抗体 (IAA)、空腹及餐后 2小时胰岛素、C -P ,另予每例测身高和体重 ,计算BMI。结果　DM组抗体总阳性率高于对照组 ;与肥胖及超重组 (BMI >2 3kg/m2 )相比 ,非肥胖组 (BMI≤2 3kg/m2 )抗体阳性率明显增高 ,抗体阳性组胰岛素和C肽水平低于阴性组。结论　临床初步诊断的 2 -DM者胰岛 β细胞自身抗体的检测 ,有助于LADA的早期诊断和其 β细胞功能的保护。Objective To diagnose LADA early by GADAb,ICA and IAA measurement,then protect the function of islet β cell.Methods GADAb,ICA and IAA were measured in 130 newly diagnosed type 2 diabetics by clinical characteristic and 50 normal subjects by ELISA or RIA,Fasting insulin and C-P,postprandial insulin and C-P also were measured in all participants,Body weight and height were recorded for calculating BMI.Results The positive rates of auto-antibodies in diabetics were higher than those in controls,The positive rates of auto-antibodies in fat or overweight diabetic group(BMI>23 Kg/m 2) were increased significantly compared with non-fat diabetic group;The levels of fast insulin and C-P,postprandial insulin and C-P in diabetic patients with positive auto-antibodies were lower than those in auto-antibody negative patients.Conclusion GADAb,ICA and IAA measurements have value for distinguishing LADA early from the newly diagnosed type 2 diabetics by clinical characteristic,early diagnosis of LADA is helpful for the protection of islet β cell function.

关 键 词：GADA LADA 早期诊断 BMI 联合检测 2-DM 对照组 IAA 体重 保护 

分 类 号：R587.1[医药卫生—内分泌] R446[医药卫生—内科学]