灵芝干膏和灵芝孢子粉对小鼠免疫功能的影响  

Research of the Dry Extract and Spore Powder of Ganoderma lucidum on the Immunoregulation Function of the Mice

作　　者：朱继红[1] 李铁民[1] 陈颖[1] 杨潇[1] 丛娜[1] 初洪文[1] 李昱[1] 

机构地区：[1]辽宁大学生命科学系,沈阳110036

出　　处：《食用菌学报》2004年第4期24-27,共4页Acta Edulis Fungi

基　　金：辽宁省教育厅推广计划基金项目"灵芝系列产品的研制与开发"(20023288)的部分内容

摘　　要：灵芝干膏、破壁和未破壁灵芝孢子粉对小鼠脾重/体重比值无显著影响;可显著提高淋巴细胞转化率,但三者的药效在统计学上无显著差异;这三种药物成分可显著增强小鼠腹腔巨噬细胞酸性磷酸酶(ACP)的活性,灵芝干膏增强ACP酶活性维持的时间较长,灵芝孢子粉则在一定时间范围内酶活较高,破壁率越高,所需剂量越小,达到最高酶活所需时间越短。The immunoregulation effect of the dry extract, sporederm-broken(SB) and sporedem-nonbroken(SN) spore powder of Ganoderma lucidum on the mice was studied. And the spleen/body weight rate, lymphocyte transformation rate and the activity of acid phosphatase(ACP) of the abdominal cavity macrophages of the mice were measured. The experiment results showed that these ingredients couldn't significantly affect the spleen/body weight rate, but could significantly improve the percentage of lymphocyte transformation, though there were no obvious statistics differences among them, and that the dry extract, SB and SN spore powder of G.lucidum could significantly enhance the ACP activity of the macrophages of the mice, merely the dry extract could kept ACP activity at a higher degree for a relatively longer period, but for the spore powder, the higher ACP activity could only be kept during a definite period of time, and the higher the SB ratio, the shorter the time and the smaller the dose needed to reach the maximum enzyme activity.

关 键 词：灵芝干膏 灵芝孢子粉 小鼠 免疫功能 淋巴细胞转化率 巨噬细胞 酸性磷酸酶 

分 类 号：R285[医药卫生—中药学]