莫达芬尼酸及莫达芬尼砜的核磁共振波谱研究  

A Study on Nuclear Magnetic Resonance Spectrum of Modafinil Acid and Modafinil Sulfone

作　　者：陆江海 王杉 崔凯荣 邓静 吴侔天 张长久 

机构地区：[1]国家运动医学研究所兴奋剂检测中心,北京100029

出　　处：《贵阳医学院学报》2004年第6期497-498,共2页Journal of Guiyang Medical College

摘　　要：目的 :对莫达芬尼酸和莫达芬尼砜进行核磁共振波谱 (NMR)研究。方法 :采用 1D NMR(1H、13 C NMR、DEPT)和 2D NMR(1H 1HCOSY、HMQC、HMBC)等现代核磁技术检测莫达芬尼酸和莫达尼酸的结构。结果 :归属了莫达芬尼酸和莫达芬尼砜的H、C谱线。结论 :首次报道了莫达芬尼酸和莫达芬尼砜的碳谱数据。Objective: To study the nuclear magnetic resonance(NMR)spectrum of modafinil acid and modafinil sulfone. Methods: Complete 1H NMR and 13 C NMR assignments of these compounds were carried out using DEPT, HMQC and HMBC techniques. Results: The H and C NMR spectra of the two compounds were sorted. Conclusion: The 13 C NMR data of them are reported for the first time. [

关 键 词：莫达芬尼酸 莫达芬尼砜 磁共振波谱学 

分 类 号：R971.1[医药卫生—药品] R962[医药卫生—药学]