Karyotypic analysis of intersexuality in Chinese from Taiyuan  

作　　者：Zhen-Guo MI Xiao-Feng YANG Tao LAN Department of Urology, First Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, China 

出　　处：《Asian Journal of Andrology》2000年第2期155-157,共3页亚洲男性学杂志（英文版）

摘　　要：Aim: To analyze the kayrotypic patterns of 33 cases of intersexuality in Chinese from Taiyuan, China in order tofurther clarify its mechanism of development and the interrelationship between karyotype and phenotypic sex. Meth-ods: High-resolution GTG-banding chromosome technique was used to analyze the karyotype patterns. Results:In these patients, 57.58% were male pseudohermaphrodites (46, XY), 18.18%, female pseudohermaphrodites (46,XX), 12.12%, true hemaphrodites, and 12.12%, other karyotypes, Although testes can be seen in 88.8% of kary-otypes with Y chromosome, 73.68% of the patients were of female social sex. In 42.82% of patients the social sex isin conformity with their karyotypes. There were 2 cases of male pseudohennaphrodites, where the sex chromosome wasnormal, but abnormalities were found in chromosomes 9, 13, or 14. Conclusion: Sex chromosomes determine thedirection of gonadal and sex differentiation, while the development of the normal gonad and extemal genitalia shouldhave the participation of many autosomal chromosomes as well.Aim: To analyze the kayrotypic patterns of 33 cases of intersexuality in Chinese from Taiyuan, China in order tofurther clarify its mechanism of development and the interrelationship between karyotype and phenotypic sex. Meth-ods: High-resolution GTG-banding chromosome technique was used to analyze the karyotype patterns. Results:In these patients, 57.58% were male pseudohermaphrodites (46, XY), 18.18%, female pseudohermaphrodites (46,XX), 12.12%, true hemaphrodites, and 12.12%, other karyotypes, Although testes can be seen in 88.8% of kary-otypes with Y chromosome, 73.68% of the patients were of female social sex. In 42.82% of patients the social sex isin conformity with their karyotypes. There were 2 cases of male pseudohennaphrodites, where the sex chromosome wasnormal, but abnormalities were found in chromosomes 9, 13, or 14. Conclusion: Sex chromosomes determine thedirection of gonadal and sex differentiation, while the development of the normal gonad and extemal genitalia shouldhave the participation of many autosomal chromosomes as well.

关 键 词：pseudobermaphroditism HERMAPHRODITISM KARYOTYPING GENE CHROMOSOME 

分 类 号：R711.1[医药卫生—妇产科学]