地塞米松棕榈酸酯的NMR数据解析  

AN NMR STUDY OF DEXAMETHASONE PALMITATE

作　　者：张海艳[1] 吴鸣建[1] 董建军[2] 付经国[2] 陈涛 赵天增[2] 

机构地区：[1]郑州大学化学系,河南郑州450052 [2]河南省生物技术开发中心,河南郑州450002 [3]西安力邦企业,陕西西安710075

出　　处：《波谱学杂志》2004年第4期405-411,共7页Chinese Journal of Magnetic Resonance

摘　　要：参考地塞米松在D2 O中检测的的1H、19FNMR数据、棕榈酸的1H、13CNMR标准图谱数据和Lindeman Adams经验公式 ,对地塞米松棕榈酸酯进行了1H和13CMNR检测 ,通过DEPT和1H 1HCOSY、HMQC、HMBC等Dexamethasone palmitate incorporated into liposomes (liposteroid) was developed as a targeting anti-inflammatory drug (limethason) used mainly for treatment of rheumatoid arthritis. In this study, 1D (~1H, ^(13)C NMR and DEPT) and 2D (~1H-~1HCOSY,HMQC and HMBC) NMR spectra of dexamethasone palmitate in chloroform were obtained, assigned and analyzed. The structure of dexamethasone palmitate in chloroform was elucidated by referring to the ~1H and ^(19)F NMR spectra of dexamethason in the aqueous solution, the standard ~1H and ^(13)C NMR spectra of palmitate and the Lindeman-Adams experimental formula.

关 键 词：地塞米松 棕榈酸 NMR技术 ^13C HMBC 检测 数据 化合物 经验公式 解析 

分 类 号：O482.53[理学—固体物理] R284.1[理学—物理]