CD44s及变异体v6在卵巢子宫内膜异位囊肿及在位内膜中的表达  

Expression of CD44s and isoform v6 in ovarian endometriotic cysts and its eutopic endometriums

作　　者：周凯[1] 何福仙[2] 瞿文珍[1] 许张晔[1] 王群姬[3] 万丽[3] 

机构地区：[1]温州医学院第一附属医院妇产科,浙江温州325000 [2]华中科技大学同济医院妇产科 [3]温州医学院第一附属医院病理科,浙江温州325000

出　　处：《温州医学院学报》2004年第6期436-438,共3页Journal of Wenzhou Medical College

摘　　要：目的 :研究CD4 4s及变异体v6与子宫内膜异位症 (EM)发病之间的关系。方法 :采用SP免疫组化方法检测CD4 4s及变异体v6在 2 0例卵巢异位子宫内膜及相应在位内膜和 2 0例正常内膜组织中的表达。结果 :①正常内膜腺上皮细胞在增生期不表达CD4 4s及变异体v6 ,分泌期大部分表达。②在位内膜腺上皮细胞表达规律与正常相似 ,但在增生期已有部分 (3/ 10 )出现CD4 4s表达。③卵巢异位内膜腺上皮细胞CD4 4s表达强度明显高于对照组 (P <0 .0 5 ) ,变异体v6表达强度与对照组比较差异无显著性。④间质细胞不管增生期还是分泌期只表达CD4 4s ,不表达变异体v6。卵巢异位内膜间质细胞表达强度明显强于对照组 (P <0 .0 5 )。结论 :①CD4 4s及变异体v6在正常子宫内膜腺上皮细胞中表达并呈周期性改变 ,推测其表达可能与卵巢激素调控有关。②异位内膜CD4 4s的表达增强可能与异位内膜黏附腹膜有关。Objective:To study the relationship between the expression of CD44s and isoform v6 and the pathogensis of endometriosis.Methods:The expressions of CD44s and isoform v6 were detected with SP immunohistochemiscal technic in 20 cases of ovarian endometriotic tissues and matching eutopic endometriums and 20 cases of normal endometriums.Results:①The positive expressions of CD44s and isoform v6 were observed in most of secretory pattern of normal glandular epithelial cells and negative in a proliferative pattern.②The expressed regulation of CD44s and isoform v6 in glandular epithelium of eutopic endometrium was same as the normal group, but there was expression of CD44s in a proliferative pattern(3/10).③The expression intensity of staining of CD44s in glandular epithelium of ovarian ectopic endometrium was significantly higher than that in normal group (P<0.05).The expression of isoform v6 had no statistic significance compared with normal group.④The stroma was only positive for CD44s both in proliferative and secretory patterns, and negative for isoform v6. The expression intensity of staining of CD44s in stromal cells of ovarian ectopic endometrium was significantly higher than that in normal group(P<0.05).Conclusion:①The expression of CD44s and isoform v6 in glandular epithelium of normal endometrium shows a cyclic change, which means that its expression of CD44 may be correlated with ovary hormonal regulation.②The strong expression of CD44s in endometriotic tissue may play an important role in the adhesion between the endometriotic tissue and peritoneum.

关 键 词：子宫内膜异位症 黏附分子 CD44 免疫组织化学 

分 类 号：R711.71[医药卫生—妇产科学]