小儿体外循环前后中性粒细胞弹性蛋白酶的动态变化  

Dynamic change and significance of neutrophil elastase before and after cardiopulmonary bypass in pediatric cardiac surgery

作　　者：洪海筏[1] 王胜利[1] 胡型锑[1] 赵曙光[1] 杨美高[1] 黄宪平[1] 

机构地区：[1]温州医学院第二附属医院心胸外科,浙江温州325027

出　　处：《温州医学院学报》2004年第6期439-440,共2页Journal of Wenzhou Medical College

摘　　要：目的 :研究小儿心脏手术CPB前后中性粒细胞弹性蛋白酶 (NE)的改变及其意义。方法 :30例室间隔缺损 (VSD)患者 ,按有无肺动脉高压 (PH)分为无PH组 (A组 ) 15例 ,PH组 (B组 ) 15例。于CPB前 ,CPB结束后 0 ,1,3,2 4h分别抽取桡动脉血 3ml,测定血浆NE的含量变化。结果 :两组患儿血浆NE水平 ,均于CPB后明显升高 (P <0 .0 1) ;在CPB后 ,B组血浆NE水平高于A组 (P <0 .0 5 )。结论 :先心伴PH患儿CPB后血浆NE含量明显高于先心未伴PH的患儿。CPB后中性粒细胞激活 ,并通过NE介导肺损伤的发生。Objective:To investigate change and signification of neutrophil elastase(NE) before and after cardiopulmonary bypass(CPB) in pediatric cardiac surgery.Methods: Thirty chidren with VSD were enrolled in this study. They were devided into two groups:group A(no-PH group), group B(PH group). The plasma NE was assayed at pre-CPB and 0 h, 1 h, 3 h and 24 h after CPB.Results:The plasma level of NE increased significantly after CPB in two groups. The plasma NE concentration in B group was higher than that in A group.Conclusion:Plasma NE concentration in congenital heart disease kids with PH is significantly higher than that in congenital heart disease kids without PH. After CPB, neutrphil elastase is activated and lung injury may occur through NE.

关 键 词：体外循环 中性粒细胞激活 中性粒粒细胞弹性蛋白酶 肺损伤 

分 类 号：R654[医药卫生—外科学]