钙通道阻滞剂对离体大鼠门静脉的作用  

Effects of Calcium-channel Blocker on Isolated Rat Portal Vein

作　　者：李定国[1] 陆汉明[1] 陈建伟 蒋祖明[1] 李宣海[1] 顾鹤定[1] 俞霭瑶[3] 冯菊妹[3] 

机构地区：[1]上海第二医科大学附属新华医院内科 [2]上海市南汇县东海农场职工医院 [3]上海第二医科大学药理学教研室

出　　处：《上海第二医科大学学报》1993年第1期35-38,共4页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：研究了硝苯啶、维拉帕米(异搏停)、脑益嗉及汉防已甲素对由钾离子或去甲肾上腺素引起收缩的离体大鼠门静脉作用。这些药物均能使钾离子和去甲肾上腺素剂量-反应曲线呈非平行右移,并降低最大反应值。硝苯啶的PD_2值分别为7.1204和6.3462,维拉帕米为6.1754和7.1049,汉防已甲素为5.4960和5.5121以及脑盖嗉为5.3406和3.8732。上述结果说明这些药物对门静脉具有扩张作用,但作用模式并不一致。The effects of nifedipine (Nif), verapamil (Ver), tetrandrine (Tet) and cinnarizine (cin) on potassium-or noradrenaline-induced contraction in the isolated strips of rat portal vein were studied. All of these calcium-channel blockers antagonized the actions of potassium and noradrenaline in a non-competitive manner. The shifted the dose-response curves of potassium and noradrenaline to the fight with peak values somewhat declined. The PD_2 values of Nif against potassium and noradrenaline were 7.1204 and 6.3462; those for Ver 6.1753 and 7.1049; those for Tet, 5.4960 and 5.5121; and those for Cin, 5.3406 and 3.8732, respectively. The results suggested that all these agents were effective vasodilators for the portal vein, although their mode of action may not be identical.

关 键 词：钙拮抗剂 大鼠 门静脉 药理学 

分 类 号：R962[医药卫生—药理学]