P38丝裂原活化蛋白激酶和核转录因子κBP65在胸部爆炸伤致急性肺损伤中的作用  

Role of P38 MAPK and NFκBP65 in the acute lung injury induced by chest explosive trauma

作　　者：侯晓彬[1] 易定华[2] 李廷慧[3] 段维勋[2] 张金洲[2] 胡沛臻[2] 刘维永[2] 

机构地区：[1]上海交通大学附属第一人民医院,上海200080 [2]第四军医大学西京医院 [3]解放军第三零九医院

出　　处：《中华急诊医学杂志》2005年第1期26-29,共4页Chinese Journal of Emergency Medicine

基　　金：全军"十五"指令性课题 ( 0 1L0 60 )

摘　　要：目的　探讨P38丝裂原活化蛋白激酶 (P38MAPK)和核转录因子κBP6 5 (NFκBP6 5 )活化在胸部爆炸伤致急性肺损伤 (ALI)中的作用。方法　应用胸部爆炸伤致ALI动物实验模型 ,原位分子杂交技术检测P38MAPK和NFκBP6 5mRNA表达情况 ,并与致伤后ALI发病程度进行相关性统计分析。结果　肺组织中P38MAPK和NFκBP6 5mRNA表达情况与PaO2 ,P (A a)O2 、TNF α及IL 6水平呈正相关 ,与急性肺损伤肺炎症反应的严重程度存在一致性。结论　P38MAPK和NFκBP6 5活化在胸部爆炸伤致急性肺损伤 (ALI)中起着重要作用 。Objective To study the role of P38 MAPK and NFκB P65 activation in the acute lung injury(ALI) induced by chest explosive trauma. Methods ALI animals were induced by using chest explosive trauma,the expressions of P38 MAPK and NFκB P65mRNA were examined by in situ hybridization,and their relation with the severity of ALI was analyzed.Results The expressions of P38 MAPK and NFκB P65mRNA were closely related to PaO 2,P(A-a)O 2, TNF-α and IL-6,and linear correlated with the severity of pulmonary inflammation in ALI. Conclusion P38 MAPK and NFκB P65 activation play an important role in the ALI after chest explosive trauma. lessening their activation may be an effective way to treat ALI.

关 键 词：爆炸伤 胸部 ALI 急性肺损伤 NFΚB P38MAPK 核转录因子ΚB 发病程度 防治 相关性 

分 类 号：R82[医药卫生—临床医学]