Fas和FasL在鼻息肉组织中的表达及意义  

Expression of Fas and FasL in Nasal Polyps and its Significance

作　　者：魏丽萍[1] 刘洪英[1] 张春丽[1] 范华[1] 

机构地区：[1]济南铁路中心医院耳鼻咽喉科,250001

出　　处：《中国眼耳鼻喉科杂志》2005年第1期25-26,共2页Chinese Journal of Ophthalmology and Otorhinolaryngology

摘　　要：目的通过检测 Fas 和 FasL 在鼻息肉中的表达,研究细胞凋亡和 Fas/FasL 系统在鼻息肉发病机制中的作用。方法用免疫组化方法检测 Fas 和 FasL 在35例鼻息肉和17例正常下鼻甲组织中的表达。对Fas 和 FasL 阳性细胞的类型、分布特点进行分析。结果 1.Fas 和 FasL 在鼻息肉组织中的表达均较正常下鼻甲组织明显增强,差异有显著性。2.Fas 在上皮细胞和间质细胞中都有阳性表达,主要表达于息肉表面的上皮细胞和间质内的炎性细胞中。结论 1.Fas/FasL 系统介导的凋亡在鼻息肉的发病机制中有重要作用,可能是鼻息肉长期保持良性增生的重要因素。2.FasL 在鼻息肉上皮细胞中的高表达与上皮细胞的过度增生及 Fas/FasL系统的免疫监视作用有关。Purpose To illustrate the role of the Fas/FasL system in pathogenesis of nasal polyps,we investigated expressions of Fas and FasL in nasal polyps by immunohistochemical medthod.Methods The experssions of Fas and FasL were determinated in 35 tissue samples of nasal polyps and 17 controls from normal inferior turbinates respectively by immunohistochemical medthod.The cell type and distributed were analysed in positive expression of Fas and FasL.Results 1.There was a significant over-expression of Fas and FasL protein in nasal polyps compared to normal inferior turbinates.The difference between these two groups was significant (P<0.005).2.Fas-positive cells were localized on epithelium and inflammatory cells in nasal polyps.Conclusion 1.Fas/FasL system may play an important role in pathogenesis of nasal polyps.2.FasL may contribute to over-proliferation in epithelium of nasal polyps.

关 键 词：鼻息肉组织 高表达 FAS/FASL系统 上皮细胞 正常 下鼻甲 发病机制 间质细胞 介导 凋亡 

分 类 号：R765.25[医药卫生—耳鼻咽喉科]