细胞信号网络拓扑结构分析  

TOPOLOGICAL STRUCTURE ANALYSIS OF CELL SIGNALING NETWORKS

作　　者：代荣阳[1] 刘友平[1] 严冬梅[1] 

机构地区：[1]泸州医学院生物化学教研室,四川泸州646000

出　　处：《泸州医学院学报》2005年第1期25-28,共4页Journal of Luzhou Medical College

摘　　要：目的 :探讨细胞信号转导网络的拓扑结构属性 ,从而为复杂性细胞信号网络系统的研究提供有益帮助。方法 :首先根据已知的细胞信号转导途径以及信号转导分子间的生化作用机制的研究结果 ,构建出复杂细胞信号转导网络模型 ,进而在此模型的基础上从不同的层次对其拓扑结构属性进行分析。结果 :网络模型表现出明显的非同质拓扑结构 ,此结构属性有助于解释无尺度细胞信号网络对意外攻击具有惊人的强韧性 ;根据组织特点对节点的分类有助于对节点的网络行为进一步研究 ;对网络模型核心骨架及信号交流的分析也有助于促进对细胞复杂行为的理解。结论 :通过构建网络模型来分析细胞信号转导网络的拓扑结构属性对复杂性细胞信号系统进行研究是很有必要的。Objective: To investigate the topological structure properties of cell signaling transduction networks, in order to offer assistance for the research on the complexity of cell signaling system. Methods: Firstly, a model of complex cell signaling transduction networks was constructed in terms of available cell signaling transduction pathways and the research data of the mechanisms of biochemical action among signaling molecules. Next, its topological structure properties were analyzed at several different levels. Results: This network model obviously shows inhomogeneous topological structure, which is conducive to explaining the robust tolerance of scale-free signaling networks against errors and attacks. The categorizing of nodes based on the characters of nodes organization could contribute to further study of nodes network behavior. The analysis of core framework and signaling interflow of this network model could also promote the comprehension of cellular complex behaviors. Conclusion: It is imperative to study the complexity of cell signaling system by constructing networks model for analysis of its topological structure properties.

关 键 词：拓扑结构 细胞信号转导网络 复杂性 

分 类 号：Q811.3[生物学—生物工程]