测定药物中的痕量杂质  

Determination of Impurity in Drugs Using On-line Concentration Technique in CTAB Buffer Solution

作　　者：刘妍[1] 杨更亮[2] 

机构地区：[1]邯郸学院化学系,河北邯郸056005 [2]河北大学化学与环境科学学院,河北保定071002

出　　处：《河北师范大学学报（自然科学版）》2005年第1期66-69,共4页Journal of Hebei Normal University：Natural Science

基　　金：国家自然科学基金资助项目(20075005);河北省自然科学基金资助项目(202096)

摘　　要：利用在线富集技术测定药物佐米曲坦和盐酸美西律中的痕量杂质.比较了分别在十六烷基三甲基溴化铵(CTAB)和十二烷基磺酸钠(SDS)存在下在线富集的效果,考察了CTAB浓度、进样时间、缓冲液pH值对富集的影响.结果表明:利用SDS富集会出现假峰现象,而在CTAB改向条件下能得到较好的富集效果,其优化条件为15mmol/LNa2B4O7+1.0mmol/LCTAB(pH=9.18),进样时间100s.方法可行,准确度好.An on-line concentration technique was developed to determinate trace impurity in Zolmitriptan and Mexitil.The experiment compared the effect of concentration in CTAB and SDS buffer solution.The effect of CTAB concentration,the injection time,pH value of buffer on the concentration was investigated.False peaks appeared when sample injection was long and SDS concentration was high,but satisfactory concentration could be gained in CTAB buffer solution.It had been proved that the optimum concentration buffer solution was 15?mmol/L Na_2B_4O_7+1.0?mmol/L CTAB(pH=9.18) and the optimum injection time was 100?s.The method is feasible and accurate.

关 键 词：CTAB 进样 在线富集 痕量杂质 假峰 十六烷基三甲基溴化铵 十二烷基磺酸钠 下利 药物 SDS 

分 类 号：O657[理学—分析化学] O647.2[理学—化学]