丝裂霉素C还原代谢机理研究  

Study on the Reductive Metabolism of Mitomycin C

作　　者：丁敏[1] 程圭芳[1] 赵洁[1] 何品刚[1] 方禹之[1] 

机构地区：[1]华东师范大学化学系,上海200062

出　　处：《分析化学》2005年第1期5-8,共4页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金资助项目(No. 29875008)

摘　　要：采用光谱电化学方法,结合循环伏安法、紫外 可见光谱、圆二色光谱等多种手段,提出了丝裂霉素C(MMC)的还原代谢机制。其还原活化为MMC首先从电极上得到一个电子,形成半醌自由基,随后脱去甲氧基形成吲哚半醌自由基,接着环乙亚胺基水解开环,最后吲哚半醌自由基歧化得到吲哚醌和吲哚氢醌。By means of in-situ spectroelectrochemical techniques, the electroreduction activation of Mitomycin C ( MMC) has firstly been investigated with the aids of cyclic voltammetry, ultraviolet-visible and circular dichroism spectrophometry. The reduction of MMC is a electrochemistry-chemistry-electrochemistry process in which intermediate semi-quinone radicals are created. Through hydrolyzing, opening of aziridine triangle ring demethoxylizing, MMC comes to its disproportionation products hydroindolquinone and indolquinone.

关 键 词：丝裂霉素C 自由基 MMC 乙亚胺 氢醌 甲氧基 代谢机制 还原 歧化 吲哚 

分 类 号：R96[医药卫生—药理学]