电喷雾电离质谱鉴定合成莱克多巴胺的副反应产物  

Identification of Products Formed in Side Reactions in Ractopamine Synthesis with Electrospray Ionization-Mass Spectrometry

作　　者：陈建新[1] 陈杖榴[1] 马安德 陈伟媚[3] 杨志凌[3] 

机构地区：[1]华南农业大学兽医学院,广州510642 [2]第一军医大学分析测试中心,广州510515 [3]广东省农科院畜牧研究所,广州510640

出　　处：《分析化学》2005年第1期63-65,共3页Chinese Journal of Analytical Chemistry

摘　　要：采用电喷雾电离质谱(ESI MS)结合碰撞诱导解离 (CA)技术分析了合成莱克多巴胺 (Ractopamine)产品溶液中目标化合物和副反应产物。根据一级和二级质谱图确定了反应副产物的化学结构, 4种副产物分别为Ractopamine脱去水分子、再氢化及烃羟基甲醚化和乙醚化而形成的。质谱方法提供的分子量、分子结构信息对改进反应条件、减少副反应发生、提高产品收率具有指导作用。Electrospray ionization mass. spectrometry ( ESI-MS) and collisional activation technology were used to determine target compound and compounds that were produced,in side reactions in ractopamine synthesis. Chemical structures of the-four compounds formed in side reactions were identified based on ESI-MS and MS'. It is believed that dehydration, hydrogenation, methyl etherification and ethyl etherification of alcohol ractopamine may result in formation of the four compounds during the process of ractopamine synthesis.

关 键 词：副反应 多巴胺 诱导 CA 鉴定 副产物 化学结构 合成 产品收率 甲醚 

分 类 号：S859.79[农业科学—临床兽医学]