气相色谱-质谱法测定复方薄荷脑滴鼻液中2组分含量  

Determination of the Contents of Camphor and Menthol in Compound Menthol Nose Drops by GC-MS

作　　者：余继英[1] 何林[1] 孙世明[1] 王怀芾[1] 曾明辉[1] 

机构地区：[1]四川省人民医院药剂科,成都市610072

出　　处：《中国药房》2005年第1期60-62,共3页China Pharmacy

摘　　要：目的 :建立以气相色谱 -质谱法测定复方薄荷脑滴鼻液中薄荷脑及樟脑含量的方法。方法 :以DM -5(0 25mm×30m)弹性石英毛细管柱为色谱柱 ,乙萘酚为内标 ,升温程序为80℃～150℃ ,分别选择M/Z为95、71的离子碎片峰对樟脑、薄荷脑进行检测。结果 :樟脑的浓度线性范围为1 04～10 40μg/ml(r=0 9998) ,回收率为101 2 % ;薄荷脑的浓度线性范围为0 824～8 24μg/ml(r=0 9999) ,回收率为99 98 %。结论 :本方法快速、准确 ,可用于同类制剂的质量控制。OBJECTIVE:To determine the camphor and menthol in compound menthol nose drops by GC-MS.METHODS:Camphor and menthol were determined by GC-MS with SIM mode andβ-naphthol was selected as the inˉternal standard.RESULTS:The calibration curves of camphor and menthol were linear in the ranges of1.04～10.40μg/ml(r=0.9998)and0.824～8.24μg/ml(r=0.9999)and the recoveries were101.2%and99.98%respectively.CONCLUSION:The method is quick,accurate and also suitable for quality control of the preparation.

关 键 词：气相色谱-质谱法 樟脑 薄荷脑 含量测定 

分 类 号：R927.2[医药卫生—药学]