金双歧在慢性深度黄疸肝炎治疗中的作用(英文)  

Effect of Golden Bifidobacterium on chronic hepatitis with deep jaundice

作　　者：应若素[1] 谢建萍[1] 

机构地区：[1]中南大学湘雅医院感染病科,湖南长沙410008

出　　处：《中国现代医学杂志》2005年第1期31-33,37,共4页China Journal of Modern Medicine

摘　　要：目的探讨金双歧在慢性深度黄疸肝炎治疗中的具体作用及疗效。方法收集如下血标本:慢性深度黄疸乙型肝炎患者80例,配对设计,随机分为对照组、治疗组。对照组常规护肝治疗,治疗组在此基础上加用金双歧治疗。治疗前后分别采取静脉血3ml。采血当日送检肝功能。分别用鲎实验改良基质法进行内毒素定量测定,放射免疫方法(RIA)测定肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)。结果金双歧治疗组与对照组相比,内毒素、TNF-α、IL-6与总胆红素(TBIL)水平下降,其差异有显著性意义(P <0.05),并且,治疗组并发症发生较少。结论金双歧能减轻慢性深度黄疸肝炎患者的内毒素血症,降低细胞因子水平,可作为防治严重肝病的常规辅助疗法。To study the effects and mechanism of Golden Bifidobacterium on chronic viral hepatitis with deep jaundice. 80 patients with the disease were selected (randomly divided into control group and treatment group). The treatment group was given Golden Bifidobacterium on the basis of the same routine liver protection therapy with the group. The blood samples were respectively collected before and after therapy. The liver function was obtained on the collecting blood day. After all the samples were gathered, endotoxin, tumor necrosis factor-α(TNF-α)and interleukin-6 (IL-6) were determined. Endotoxin was detected by using limulus lysate test (LLT), and the last two indexes were detected by using radioimmunoassay (RIA). After Golden Bifidobacterium therapy, the differences of the three indexes and total bilirubin (TBIL) between the treatment group and the control group were significant; and the complications in the treatment group were reduced. [Conclusion] Golden Bifidobacterium can abate the endotoxemia of the patients, and then can reduce the levels of the cytokines, so it can be used as a routine assistant therapy for the severe liver diseases.

关 键 词：慢性肝炎 内毒素 肿瘤坏死因子-α 白细胞介素-6 双歧杆菌活菌制剂 

分 类 号：R512.61[医药卫生—内科学]