骨组织工程支架材料聚磷酸钙体外降解规律的研究  

Study on the Degradation in Vitro of Calcium Polyphosphate for Bone Tissue Engineering

作　　者：邱凯[1] 万昌秀[1] 陈馨 唐昌伟[1] 陈元维[1] 

机构地区：[1]四川大学高分子科学与工程学院,四川成都610065 [2]国家医疗保健器械工程技术研究中心,广州510500

出　　处：《四川大学学报（工程科学版）》2005年第1期61-64,共4页Journal of Sichuan University (Engineering Science Edition)

基　　金：国家自然科学基金资助项目(30370411;50472091)

摘　　要：为了解决骨组织工程中支架材料的降解速度应与细胞的生长速率相匹配,通过对原料煅烧过程的分析,提出了聚合度的计算方法,并制备出不同聚合度的材料。通过对材料烧结温度的试验,制得了不同晶型的聚磷酸钙多孔材料。结果表明,随着聚合度的增加,材料的抗压强度增大,降解速率变小;不同晶型的材料具有不同的降解速率,非晶CPP最快完全降解为17d,α-CPP最慢30d约降解为5%。凭借其独特的无机聚合物结构及降解性能,实现可控速率的降解。In order to resolve the degradation velocity of scaffolds matching with the growth velocity of cells, the calcium polymphosphate (CPP) with different polymerization degree were prepared by controlling the calcining time. Results showed that with the increase of polymerization degree, the weight loss during the degradation decreased, contrarily the strength of CPP increased. The full weight loss period of amorphous CPP is 17 days and the weight loss of a-CPP is about 5 % during the period of 30 days. Because of its inorganic polymeric structure and the degradability, the controllable degradation of CPP can be possibly achieved.

关 键 词：聚磷酸钙 聚合度 晶型 降解 

分 类 号：R318[医药卫生—生物医学工程]