星点设计-效应面法优化水飞蓟素固体脂质纳米粒的制备  

Optimized Preparation of Silymarin-loaded Solid Lipid Nanoparticles by Central Composite Design and Response Surface Method

作　　者：何军[1] 奉建芳[1] 庞家忠[1] 侯世祥[2] 

机构地区：[1]上海医药工业研究院药物制剂部,上海200437 [2]四川大学华西药学院,四川成都610041

出　　处：《中国医药工业杂志》2005年第1期18-21,共4页Chinese Journal of Pharmaceuticals

基　　金：国家"863"计划项目(2001AA218011);上海市纳米科技与产业发展促进中心项目(0143nm063)

摘　　要：以冷却-匀质法制备水飞蓟素固体脂质纳米粒,采用星点设计-效应面法优化制备工艺,以平均粒径、包封率、载药量为评价指标,考察了药物与Compritol888ATO的重量比、乳化剂用量、泊洛沙姆占乳化剂的比例、乳匀压力4因素对制备工艺的影响,对结果分别进行多元线性和二项式方程拟合,用效应面法预测最佳工艺条件。结果表明,各指标的二项式拟合方程均优于多元线性回归方程,以优化条件制备的样品平均粒径为190.9nm、包封率为95.9%、载药量为8.6%。The silymarin-loaded solid lipid nanoparticles(Sly-SLN) were prepared by cold homogenization technique. The formulation was optimized using central composite design and response surface method. The influence factors such as the ratio of drug to compritol 888 ATO, amountofemulsifier,the ratio of poloxamer188 in theemulsifier and homogenization pressure were investigated using mean diameter, entrapment efficiency and drug loading as evaluation parameters. The data were imitated using multi-linear equation and second-order polynomial equation. Theresults showed that the latter was prior to the former. According to the optimal conditions, the mean diameter, entrapment efficiency and drug loading of the prepared Sly-SLN were190.9nm, 95.9% and 8.6%, respectively.

关 键 词：水飞蓟素 固体脂质纳米粒 星点设计 效应面法 

分 类 号：R944.9[医药卫生—药剂学]