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作 者:臧银善[1]
机构地区:[1]江苏省邳州市人民医院风湿免疫科,江苏邳州221300
出 处:《安徽医药》2005年第2期97-98,共2页Anhui Medical and Pharmaceutical Journal
摘 要:目的 研究白芍总苷 (TGP帕夫林 )治疗幼年特发性关节炎 (JIA)的疗效及不良反应。方法 采用分组对照研究 ,治疗组4 2例应用白芍总苷早期联合应用激素、非甾体抗炎药 (NSAIDs) ,后期以TGP为主 ,对照组 2 6采用甲氨喋呤 (MTX) ,治疗 6个月 ,观察关节晨僵时间、疼痛指数、血沉 (ESR)、C -反应蛋白 (CRP)等指标 ,分析两组疗效 ;并总结二者的不良反应。结果 治疗组在关节晨僵、疼痛指数、ESR、CRP和总有效率等与对照组无显著性差异P >0 0 5 ;但治疗组激素平均用量比对照组少 ,激素疗程明显缩短P <0 0 5 ;肝功能损害等严重不良反应少。结论 白芍总苷对幼年特发性关节炎有效 ,疗效与甲氨喋呤相当 ,可以减少激素的用量 ,缩短激素的疗程 ,不良反应少。Aim To study curative effects and side-effects of total glucosides of paeony(TGP)on juvenile idiopathic arthritis(JIA). Methods 68 patients were divided into two groups:42 patients(TGP group) were treated by TGP in combination with glucocorticosteroid and nonsteroid anti-inflammatory drugs,(NSAIDs), 26 patients (MTX group) were treated by methotrexate for 6 months. Time of morning-stiff, pain-index, ESR and CRP were observed.Results There was no significant difference between TGP group and MTX group on time of morning-stiff、pain-index, ESR, CRP and total curative ratio(P>0.05). But in TGP group, average dose of glucocorticosteroid was fewer, and course of treatment with glucocorticosteroid was shorter than MTX group. While, Adverse effects were fewer in TGP group.Conclusion TGP is effective on JIA to reduce the gross of glucocorticosteroid and shorten the period of treatment. The side-effects of TGP is little.
分 类 号:R272[医药卫生—中医儿科学]
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