艾滋病合并结核病患者的免疫功能临床研究  

The clinic study of the immune functions in AIDS complicated with pulmonary tuberculosis

作　　者：刘艳[1] 余卫业[1] 王晓燕[1] 乐晓华[1] 李慧涓[1] 胡毅文[1] 王辉[1] 陆普选[1] 

机构地区：[1]广东省深圳市东湖医院,深圳518020

出　　处：《中国防痨杂志》2005年第1期47-50,共4页Chinese Journal of Antituberculosis

摘　　要：目的　了解艾滋病 (AIDS)合并结核病患者的免疫功能受损情况和治疗转归。方法　分析1 997年 5月— 2 0 0 4年 3月住院的 1 1例AIDS合并结核病患者的CD4、CD8、HIV RNA及PPD试验并与同期住院结核病 31例和AIDS 2 7例相比较。结果　AIDS合并结核病组、AIDS组与结核病组比较则CD4、CD8有显著性差异、CD3无显著性差异 ,而AIDS合并结核病与AIDS比较CD3、CD4、CD8均无显著性差异。 1 1例AIDS合并结核病中 6例检测HIV RNA >3.0× 1 0 6 copy/ml,5例HIV RNA <3.0× 1 0 6 copy/ml。而 2 7例AIDS中 3例HIV RNA >3.0× 1 0 6 copy/ml,2 4例HIV RNA <3.0× 1 0 6 copy/ml,比较有显著性差异。 结论　AIDS合并结核病者免疫功能严重受损 ,与结核病比较差异显著 ,但与AIDS比较则无明显差异。合并结核病者HIV RNA较未合并者高 ,说明合并结核病者病毒复制量大 ,尤其是当AIDS合并血行播散性肺结核者死亡率高 ,抗结核治疗疗效差。Objective To investigate the damage of immune functions in AIDS complicated with pulmonary tuberculosis and to analysis the relationship between AIDS and tuberculosis to treat and prognosis.Methods Retrospective analysis was performed in 11 cases AIDS complicated with pulmonary tuberculosis patients hospitalized from May 1997 to March 2004 cases were tested T-lymphocyte subpopulation, PPD test and HIV-RNA. These tests results were compared with 27 AIDS cases and tuberculosis 31 cases in the same time hospitalized.Results The CD4 and CD8 cell level in peripheral blood was statistical significance difference (P<0.01) in the AIDS with tuberculosis, and AIDS than tuberculosis.The CD3 cell level was no statistical significance (P>0.05). 6 cases HIV-RNA viral content in AIDS with tuberculosis was >3.0×10 6 copy/ml,5 cases HIV-RNA viral content <3.0×10 6 copy/ml.It was statistical significance (P<0.01)that it was compared with AIDS 27 cases (3cases >3.0×10 6 copy/ml,24cases <3.0×10 6 copy/ml). ALL patients alive expect for two patients dead of blood distribution of pulmonary tuberculosis.Conclusion The immune functions of AIDS complicated with tuberculosis were severe destroyed.The mortality was high in ADIS complicated blood distribution of pulmonary tuberculosis and terminal AIDS complicated with pulmonary tuberculosis. The study found AIDS complicated diffusion by blood of pulmonary tuberculosis and terminal AIDS complicated with pulmonary tuberculosis viral content was high, infective was serious, harm was verse. Treatment effect of anti-tuberculous was poor.

关 键 词：结核病 AIDS HIV 患者 RNA 免疫功能 CD8 合并 显著性差异 结论 

分 类 号：R512.91[医药卫生—内科学] R52[医药卫生—临床医学]