壳聚糖在新型给药系统中的最新应用进展  

Chitosan and Its Uses as Pharmaceutical Excipient for Novel Drug Delivery Systems

作　　者：张未[1] 

机构地区：[1]中山大学附属第一医院,广州510080

出　　处：《中山大学研究生学刊（自然科学与医学版）》2004年第4期7-15,共9页Journal of the Graduates Sun YAT-SEN University(Natural Sciences.Medicine)

摘　　要：壳聚糖作为新型药用辅料,已受到越来越多的关注,对其应用的开发和研究已渗透到了药剂学的多个领域。壳聚糖作为非病毒基因载体,是近年来主要的研究热点之一;将其应用于眼部、鼻腔及口腔给药,以及作为胃部、小肠和结肠的特异性给药载体,在近两年内也有大量报道。The aim of this review is to give an insight into the many potential applications of chitosan as a pharmaceutical drug carrier.The first part of this review concerns the uses of chitosan as a vehicle for DNA delivery devices in gene therapy.The use of chitosan to manufacture sustained-release systems deliverable by other routes(nasal,ophthalmic,buccal mucosa)and for stomach-specific,small intestine-specific and colon-specific drug delivery system is discussed in the second part.

关 键 词：给药系统 口腔给药 胃部 眼部 结肠 药剂学 壳聚糖 非病毒基因 载体 研究热点 

分 类 号：R94[医药卫生—药剂学] R944[医药卫生—药学]