程序变湿变温药物稳定性试验  

Effect of programmed humidification and temperature on drug stability

作　　者：赵强[1] 詹先成[1] 李琳丽[1] 李成容[1] 林涛[1] 尹小东[1] 何宁[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《药学学报》2004年第12期1001-1005,共5页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(30171117)

摘　　要：目的　建立一种研究湿度对药物稳定性影响的简便实验方法。方法　用程序变湿和程序变温加速试验 方法,以青霉素钾为例进行药物稳定性试验。结果　程序变湿和程序变温加速试验与恒温恒湿对照试验得到的青 霉素钾的降解动力学参数基本一致。结论　程序变湿变温加速试验可以应用于药物稳定性研究。Aim To simplify the study on the effect of relative humidity and temperature on drug stability. Methods The stability of penicillin potassium as a model was studied with programmed humidifying and heating. Results Results of our programmed humidifying and heating experiments are comparable to those of traditional experiment at constant humidity and temperature. Conclusion Programmed humidifying and heating experiments are applicable to drug stability study.

关 键 词：药物稳定性 程序变湿变温加速试验 降解动力学 青霉素钾 

分 类 号：R927.11[医药卫生—药学] TQ460.72[医药卫生—药物分析学]