趋化因子和基质金属蛋白酶-9与系统性红斑狼疮活动性的关系  

Serum levels of macrophege derived chemokine and matrix metalloproteinase-9 and the relationship between serum levels and disease activity in the patients with systemic lupus erythematosus

作　　者：刘晹[1] 郑敏[2] 殷文浩[2] 鲍彰[2] 

机构地区：[1]浙江大学医学院附属第二医院风湿病学教研室,杭州310009 [2]浙江大学医学院附属第二医院皮肤科,杭州310009

出　　处：《中华检验医学杂志》2004年第12期833-835,共3页Chinese Journal of Laboratory Medicine

摘　　要：目的　探讨系统性红斑狼疮 (SLE)患者血清中巨噬细胞来源的趋化因子 (MDC)及基质金属蛋白酶 9(MMP 9)水平与疾病活动程度的关系与意义。方法　用双抗体夹心酶联免疫吸附试验检测和比较分析 36例SLE患者和 30名健康人血清MDC及MMP 9的水平。结果　SLE患者组血清MDC和MMP 9水平 (45 1± 77ng/L ,10 9± 113μg/L)比健康对照组 (6 0 6± 2 4ng/L ,35 2± 15 5μg/L)明显降低 (均P <0 0 0 1) ;经糖皮质激素治疗后血清MDC及MMP 9浓度升高 (P <0 0 0 1和P<0 0 5 )。活动期SLE血清MDC和MMP 9水平低于非活动期 (P <0 0 0 1和P <0 0 5 ) ;肾脏损害组均明显低于非肾脏损害组 (P <0 0 0 1和P <0 0 5 )。而血清MDC水平在关节炎组明显低于非关节炎组 (P <0 0 0 1) ,但MMP 9水平差异无显著意义 (P >0 0 5 )。结论　MDC和MMP 9可能参与SLE的发病机制 ,二者的血清水平可作为反映SLE活动程度、肾脏损害以疾病进展与改善的指标。Objective To investigate serum levels of macrophage derived chemokine (MDC),matrix metalloproteinase 9 (MMP 9), and to determine the relationship between serum levels and the disease activity of SLE (systemic lupus erythematosus) Methods Serum levels of MDC and MMP 9 in 36 patients of SLE and 30 healthy persons were measured by enzyme linked immuno sorbent assay Results Significantly decreased serum levels of MDC and MMP 9 were found in SLE as compared to those in controls ( P <0 001), but serum levels of MDC and MMP 9 ( P <0 001 and P <0 05) increased after treatment Serum levels of MDC and MMP 9 were lower in patients with active disease than those with inactive disease ( P <0 001 and P <0 05) Significantly decreased serum levels of MDC and MMP 9 were found in patients with renal damage than those without the damage ( P <0 001 and P <0 05) Serum level of MDC was lower in patients with arthritis than those without the damage ( P <0 001), but serum level of MMP 9 had no significant difference in two groups ( P >0 05) Conclusion The present data suggest that MDC and MMP 9 may be involved in the pathogenesis of SLE, and serum levels of MDC and MMP 9 could be markers of monitoring disease activity, renal damage, disease progression and improvement in SLE

关 键 词：MMP-9 SLE 血清 系统性红斑狼疮 患者 趋化因子 MDC 水平 结论 参与 

分 类 号：R593.241[医药卫生—内科学] R758.1[医药卫生—临床医学]