Graves病患者骨代谢变化临床分析  

Clinical analysis of bone metabolism in patients with Graves' disease

作　　者：李玫玫[1] 赵秀娥[1] 

机构地区：[1]上海市静安区中心医院内分泌科,上海200040

出　　处：《中国骨质疏松杂志》2004年第4期488-489,425,共3页Chinese Journal of Osteoporosis

摘　　要：目的探讨Graves病患者骨代谢变化的特点及作用机制。方法 测定49例Graves病患者骨代谢指标,并与甲状腺激素进行相关分析。结果 Graves病患者血BGF、ICTP、Ca、AKP和U-HOP/Cr升高,BMD下降;并与TT3、TT4正相关。结论Graves病患者骨吸收和骨形成指标均异常升高,表现为高转化骨代谢紊乱;骨吸收大于骨形成。这一代谢紊乱与甲状腺激素有关。Objective To study the characteristics of bone metabolism in the patients with Graves' disease. Methods Bone metabolism markers were measured and their correlations with thyroid hormones were analyzed in 49 patients with Graves' disease. Results BGP,ICTP,Ca, AKP, and U-HOP/Cr in patients with Graves' disease were higher than those in the normal group, whereas BMD was lower. All of these were correlated with TT3 and TT4. Conclusions There is high bone turnover rate in Graves' disease, and the abnormal bone metabolism is correlated with thyroid hormones.

关 键 词：患者 GRAVES病 骨代谢指标 骨吸收 骨形成 升高 甲状腺激素 临床分析 TT4 BMD 

分 类 号：R581.1[医药卫生—内分泌] R681[医药卫生—内科学]