中文版SF-36量表在心力衰竭患者生存质量评价中的应用研究  

Quality of life in Chinese patients with chronic heart failure as assessed by the Chinese version of SF-36

作　　者：龚开政[1] 张振刚[2] 王顺娣[1] 骆秋平[1] 孙晓宁[1] 李爱华[1] 仲玉琴[1] 凤以良[1] 

机构地区：[1]江苏省扬州市第一人民医院心血管内科,东南大学心血管疾病研究所,扬州225001 [2]扬州大学医学院临床医学系

出　　处：《中华物理医学与康复杂志》2004年第12期732-736,共5页Chinese Journal of Physical Medicine and Rehabilitation

摘　　要：目的　探讨中文版SF 3 6量表在慢性心力衰竭患者健康相关生存质量 (HRQOL)评价中的可行性。方法　采用中文版SF 3 6量表对 12 8例心衰患者的HRQOL进行评价。结果　 (1)心衰患者HRQOL各维度的得分随心功能分级增加逐步下降 ,均显著低于我国一般人群 (均P <0 .0 1)。对于不同左室舒张末期直径及运动耐量的患者来说 ,只有部分维度的比较差异有统计学意义 ,而不同左室射血分数组患者间各维度的比较差异并无统计学意义。 (2 )相关分析提示 ,各影响因素仅对部分维度呈中、低度相关 ,多元回归分析发现 ,临床病情对患者HRQOL的影响作用比常见的一些人口学指标更为重要 ,但所有因素对各维度变异的解释作用仅为 2 1.5 %～ 41.8% ,对心衰患者HRQOL综合评分、生理健康内容评分及心理健康内容评分变异的解释作用分别为 5 0 .2 % ,2 7.6% ,42 .7%。结论　 (1)心衰患者的HRQOL较一般人群已出现明显下降。 (2 )常见的一些人口学资料及临床病情共同用于解释患者HRQOL下降的意义有限 ,导致患者HRQOL下降最为主要的因素目前尚不清楚。Objective To explore the feasibility of the Chinese version SF 36 in assessment of health related quality of life (HRQOL) in patients with congestive heart failure(CHF). Methods The HRQOL was assessed in 128 patients with CHF by use of the Chinese version of SF 36. The patients cardiac structure, function and exercise capacity were evaluated, respectively, with echocardiogram and 6 minutes walk test(6 WT). Results All dimensions scores were gradually decreased along with the increase of NYHA classification in CHF patients and significantly lower than those of general population(all P <0.01). There were remarkable differences in only several dimensions between patient groups with different test results with LVEDD and 6 WT. In contrast, the systolic dysfunction(different LVEF)had no impact on the HRQOL. Correlation analysis showed that each factor is mildly to moderately correlated with only some of the dimensions. In multivariate regression analysis, the severity of condition showed relative closer relationship to HRQOL as compared with the demographic data. A combination of all the demographic and clinic variables accounted for 21.5%～41.8% of the variance of different dimensions of HRQOL and 50.2%, 27.6%, 42.7% of the variance in overall score, physical health components and the mental health components of SF 36, respectively. Conclusion The HRQOL of patients with CHF is significantly declined as compared with the general population. The predictive value of all the variables including common demographic data and clinic characteristics was limited in terms of HRQOL evaluation. The major determinants of HRQOL in patients with CHF remain unclear and further research is needed.

关 键 词：心力衰竭患者 SF-36量表 心衰 生存质量 常见 一般人群 病情 维度 得分 结论 

分 类 号：R541.6[医药卫生—心血管疾病]