钾通道阻断剂所致的蜗内直流电位改变  

CHANGES IN ENDOCOCHLEAR POTENTIAL INDUCED BY POTASSIUM-CHANNEL BLOCKERS

作　　者：王坚[1] 李倩虹[1] 董维嘉[1] 陈继生[1] 

机构地区：[1]南京铁道医学院听觉生理研究室,南京210009

出　　处：《生理学报》1993年第1期69-74,共6页Acta Physiologica Sinica

摘　　要：本实验采用耳蜗外淋巴灌流技术,观察了四氨基吡啶(4-AP)、四乙基铵(TEA)以及奎宁等不同钾通道阻断剂对豚鼠蜗内直流电位(EP)的影响。发现快钾通道阻断剂4-AP对EP无明显影响,但可改变强噪声所致EP改变的形式。TEA与奎宁则可减少负相EP(N-EP)的绝对值。实验结果提示耳蜗内有不同类型的钾离子通道存在并各具有不同的生理意义。The effect of various potassium-channel blockers, 4-aminopyridin (4--AP), tetraethylaminonium (TEA) and quinine, on the endocochlear potential(EP) was studiedin perfused guinea pig inner ears. The fast K^+--channel blocker, 4--AP, did not alterEP but changed its response model to intense noise exposure. While TEA and quininesignificantly reduced the amplitude of negative component of EP (N--EP), comparingwith a relatively smaller increase in general EP (G--EP). The results indicated the existance of different K^+--channels with different physiological functions.

关 键 词：钾通道阻滞剂 耳蜗 电位 听觉 

分 类 号：R339.16[医药卫生—人体生理学]