刺激大脑皮层体感Ⅰ区和大脑脚对大鼠脊髓背角神经元伤害感受性反应的影响  

EFFECTS OF STIMULATION OF SI CORTEX AND CEREBRAL PEDUNCLE ON THE NOCICEPTIVE RESPONSES OF SPINAL DORSAL HORN NEURONS IN THE RAT

作　　者：袁斌[1] 王歌昕[1] 庞天赐 刘新领[1] 

机构地区：[1]西安医科大学神经生理研究室,西安710061

出　　处：《生理学报》1993年第1期26-35,共10页Acta Physiologica Sinica

基　　金：国家自然科学基金

摘　　要：在大鼠用玻璃微电极细胞外记录的方法,观察了刺激皮层体感Ⅰ区(SI区)和大脑脚(CP)对皮肤强电刺激诱发的脊髓背角广动力范围(WDR)神经元长潜伏期反应(C-反应)的影响。结果表明刺激SI区对背角WDR神经元C-反应的影响以抑制为主,刺激CP的作用与刺激SI区的作用相似,但刺激CP更为有效。抑制作用的持续时间在不同神经元差别很大,短者在刺激停止后仅持续400ms,长者可达10min以上。静注纳洛酮对抑制作用无明显影响,静注二甲麦角新碱在部分神经元可使抑制作用明显减弱或完全消失,提示5-HT部分参与皮层下行抑制作用的实现,而内鸦片肽则否。Single spinal dorsal horn neurons were recorded extracellularly with glass mi-cropipettes, and the effect of stimulation Of SI cortex or cerebral peduncle (CP) wasobserved on the long latency discharges (C--fiber evoked response) of the wide dynam-ic range (WDR) neurons induced by intense electrical skin stimulation. Inhibitionwas the predominant effect of SI cortex stimulation on the C--fiber evoked responses ofWDR neurons. The effect of CP stimulation was similar to that of SI cortex stimula-tion, except that the former was much more effective than the latter. The inhibitionlasted a period of time varying from 400 ms to more than 10 min after CP stimula-tion in different neurons. Systemic naloxone had no significant effect on the inhibi-tion produced by CP stimulation. Systemic methysergide reduced or eliminated the in-hibition in a part of the neurons tested, suggesting that 5--HT, but not opioid Peptides,is involved partially in mediation of the descending inhibitory effect originating fromthe cortex.

关 键 词：大脑皮层 大脑脚 脊髓 伤害反应 

分 类 号：Q42[生物学—神经生物学]