用胆固醇代谢的房室模型速率系数来分析动脉粥样硬化程度  

THE QUANTITATIVE RELATION BETWEEN THE RATE OF CHOLESTEROL METABOLISM AND ATHEROSCLEROSIS (AS)

作　　者：李怀[1] 赵似兰[1] 戴维丽 徐宁生[2] 赵春玉[2] 赵蕊[2] 

机构地区：[1]北京医科大学生物物理教研室,北京100083 [2]北京医科大学

出　　处：《生物物理学报》1993年第4期582-586,共5页Acta Biophysica Sinica

基　　金：国家自然科学基金资助课题

摘　　要：理论上认为胆固醇逆向转运的速率与动脉粥样硬化程序呈负相关。但目前尚无完善的测试血浆脂蛋白－胆固醇体内代谢的方法。我们运用同位素＾３Ｈ－胆固醇示踪方法，建立房室模型，选取健康兔与ＡＳ兔对照，研究血浆脂蛋白转运胆固醇能力的差异，并结合ＡＳ兔主动脉斑块程度对比，结果验证了上述理论，此法如改用短半衰期同位素或稳定性同位素标记的胆固醇，就可用于人体，这可为临床判断ＡＳ程度提供一种无创性的新方法。In general, the rate of reverse cholesterol transport are strongly correlated with the development of .AS. but quantitative determination is lacking. By means of the 3H-cholesterol trace method. a three compartment model is established to describe cholesterol metabolism among plasma lipoproten. liver. and extrahapetic tissue in vivo. According to the experimental data. the rate constants from one compartment to another and the dynamic curves in each compartment have been estimated by means of the theory of system identification. These model parameters can be used to assess the ability of plasma lipoproteins in transfering cholesterol. Based on the results of the experiments, it is found that the ability of reverse cholesterol transport in the AS group was weaker than that of the control group. It is also noted that the rates of cholesterol transport are highly negative correlated with the degree of AS. We expect that this research will provide a new method and enlightenment on clinical prediction, diagnosis and treatment of AS.

关 键 词：房室模型 动脉粥样硬化 胆固醇 

分 类 号：R543.504[医药卫生—心血管疾病]