子宫内膜异位症不孕的腹腔巨噬细胞及其释放白细胞介素 I(IL-1)的活性改变  

The Alteration of Peritoneal Macrophages and IL-1 Released in the Infertility Associated with Endometriosis

作　　者：王慧贤[1] 张建岭[1] 吴敬敏[1] 赵瑞景[1] 朱志洁[2] 

机构地区：[1]河北医学院微生物学教研组免疫室,石家庄050017 [2]河北医学院附属二院妇产科,石家庄050017

出　　处：《生殖与避孕》1993年第4期254-257,共4页Reproduction and Contraception

摘　　要：本文以18例轻度子宫内膜异位症不孕者作为研究对象;以正常生育力的妇女10例作为对照。检测各例腹腔液量、腹腔巨噬细胞(MΦ)数、巨噬细胞吞噬能力及腹腔液、巨噬细胞培养上清液IL-1活性。研究结果:轻度子宫内膜异位症不孕者比正常生育对照妇女腹腔巨噬细胞数量增多,对白色念珠菌的吞噬指数及吞噬百分率增高,腹腔液及巨噬细胞培养上清液IL-1活性增强。研究表明,子宫内膜异位症不孕者腹腔巨噬细胞及其释放的IL-1均有改变,MΦ及IL-1可能是不孕的因素。In this paper,it was understaken to detect the volume of peritoneal fluid(PF)and number ofperitoneal MΦ;to assess the capecitty of MΦ phagocytosis;to determine the acttivity of IL-1 in PFand MΦ culture supernate.The PF was obtained from the 18 study objects in infertility with mildendometriosis exclusive of reproductive organs maldevelopment,oviduct obstruction,pelvic infection,and from the 10 control objects of normal fertile women undergoing oviduct sterilization.As a result of the study we have demonstrated that the number of peritoneal MΦ and thephagocytotic capacity of peritoneal MΦ was significantly higher in the experiment group than in thecontrol group,and the IL-1 activitty in PF and MΦ culture supernate from infertile women withendometriosis were also higher than that in the control group.The study showed that MΦ and IL-1are possible important factors of infertility from the alteration of peritoneal MΦ and IL-1 released ininfertile patients with endometriosis.

关 键 词：巨噬细胞 子宫内膜异位 不育症 

分 类 号：R711.6[医药卫生—妇产科学]