去氢表雄酮硫酸盐扩张宫颈作用及毒理学研究  

Cervical Ripening Effects and Toxicological Studies of Dehydroepiandrosterone Sulfate

作　　者：刘昌官[1] 林中明[1] 薛涛[1] 褚军[1] 王忠兴[1] 邢卫荣[1] 徐瑞英[1] 庄意冰 章小亮 

机构地区：[1]上海市计划生育科学研究所,上海200032 [2]汕头经济特区鮀滨制药厂,汕头515041

出　　处：《生殖与避孕》1993年第6期414-418,共5页Reproduction and Contraception

摘　　要：本文报道去氢表雄酮硫酸盐(DHA-S)促使子宫颈成熟的作用。DHA-S 可使大鼠宫颈软化和肿胀,张力降低,胶原纤维疏松,间隙增大;它还可使免子宫颈湿重增加,17β-雌二醇的血浆水平升高,DHA-S 的小鼠IV 及IP LD50(95%可信限)分别为293.3(252.32～341.0)及654.8(553.8～774.3)mg/kg。DHA-S 在微生物回复突变试验、中国仓鼠卵巢细胞培养染色体畸变试验及小鼠微核试验中,结果均为阴性。Effect of dehydroepiandrosterone sulfate(DHA-S)on ripening of the uterine cervix were studied in this paper.In rats,DHA-S induced softening and swelling of the cervix,decrease of its tension and increase of spaces between collagenous fibres.In rabbits,DHA-S increased the wetweight of the cervix and plasma levels of 17β-estradiol,Intravenous and intraperitoneal LD_(50)(95% confidencial limits)of DHA-S in mice were 0.29(0.25-0.34)and 0.65(0.55-0.77)g/kg respectively.DHA-S was found to be negative in the reverse mutation assay with microbestrains,the chromosome aberration assay in Chinese hamster ovarian cell culture and themicronucleus test in mice.

关 键 词：宫颈扩张 去氢表雄酮 毒性 致突变 

分 类 号：R984[医药卫生—药品]