广东部分地区儿童肺炎链球菌携带株耐药性调查  

Investigation of Drug Resistance of S. pneumoniae Isolates from Children Carriers in Parts of Guangdong

作　　者：陈惠玲[1] 熊剑辉[1] 廖志云 李 勇 黄桂莲 孙淑芹 

机构地区：[1]广州医学院附属市一医院检验科,广州510180 [2]广东云浮市人民医院

出　　处：《广州医学院学报》2001年第4期10-13,共4页Academic Journal of Guangzhou Medical College

基　　金：广州市重点科技攻关项目(1999)

摘　　要：目的:了解广东部分地区儿童肺炎链球菌的耐药性。方法:纸片法和Ｅｔｅｓｔ青霉素试条检测１５１株分离自广东云浮市和广州市儿童肺炎链球菌药敏。结果:纸片法测得７２株菌苯唑西林耐药(≤１９ｍｍ),对其再用Ｅｔｅｓｔ青霉素试条确证,只有２２株菌达到中介或耐药水平以上(ＭＩＣ≥０．１２５μｇ/ｍＬ),耐青霉素肺炎链球菌(ＰＲＰ)为１４．６%。纸片法测得１５１株菌对８种抗生素的敏感性:万古霉素(１００%)＞氟嗪酸(９０．７%)＞氯霉素(６７．５%)＞苯唑西林(６２．９%)＞阿齐红霉素(４８．８%)＞红霉素(４１．１%)＞复方新诺明(２１．９%)＞四环素(１６．６%);此外,多重耐药和相似耐药模式株在同一群儿童流行的表现明显。结论:提示进行耐药监测尤其是采用ＭＩＣ方法监测ＰＲＰ的重要性及采取措施预防儿童携带耐药株的必要性。ve:To test the drug sensitivity of 151 Streptococcus pneumoniae isolates from children carriers in parts of Guangdong province.Methods; Disk diffusion and E test(for penicillin) methods were used in this study.Results; 72 strains were found oxacillin resistant ( ≤19mM) with the disk diffusion method, among them, only 22 strains were found resistant to penicillin (MIC ≥0. 125 μg/mL) when tested by the E test method, with the PRP rate of 14. 6% .The sensitivities of 151 isolates of S. pneumoniae to eight antibiotics by the disk method were; vancomycin (100% ) > flxacin ( 90. 7% ) > chloraphenicol ( 67. 5% ) > oxacillin ( 62. 9% ) > azithromycin ( 48. 8% ) > erythromycin(41. 1% ) > TMP -SMZ(21.9% ) > tetracycline( 16. 6% ). Besides, there was an obvious tendency of the strains with multiple resistance and similar resistant pattern endemic within the same groups of children. Conclusion; The results indicate the importance of resistance surveillance especially with a MIC method to detect PRP and the necessity of the prevention of resistant strains in healthy children.

关 键 词：肺炎链球菌 耐药性 儿童 

分 类 号：R915[医药卫生—微生物与生化药学]