尿β_ 2-MG、Alb RIA测定对高血压病早期肾损害的诊断价值  

Clinical Significance of Detecting Urineβ_2-MC and Alb RIA in the Diagnosis of Early Hypertension Nephropathy

作　　者：汤建林[1] 赵立群[1] 李玉莹[1] 汪慧如[1] 

机构地区：[1]大理医学院非直属附属医院核医学科,云南大理671000

出　　处：《大理医学院学报》2001年第3期44-45,共2页Journal of Dali Medical College

摘　　要：目的：探讨尿β 2－ MG、 Alb对高血压病早期损害的诊断价值。方法：对 41例尿常规、血尿素氮 (BUN)和肌酐 (Cr)正常的高血压病患者作尿β 2－ MG、 Alb放射免疫测定 (RIA)。结果：高血压病组尿β 2－ MG、 Alb明显高于正常对照组 (P0. 05)。结论：高血压病时肾小球和肾小管均易受损，且关系密切，尿β 2－ MG是诊断高血压病早期肾损害的一项重要指标，与尿 Alb联合检测可提高血压病早期肾损害的诊断率，对肾脏病变部位及严重程度的判断有重要意义。Objective: To study the clinical significance of detecting urineβ 2－ MG and Alb RIA in the diagnosis of early hypertension nephropathy. Method: The urineβ 2－ microgiuobulin(β 2－ MG)and album (Alb) in 41 cases with primary hypertension, whose routine urinalysis, serum urea (BUN) and creatinine(Cr)are normal, were detected by radio－ immunoassay(RIA). Results: The urineβ 2－ MG and Alb in the primary hypertension group are obviously higher than those in the control group (P0.05). Conclusions: Both glomerule and uriniferoustabule are easily impaired correspondingly when hypertension nephropathy occurs. Urineβ 2－ MG is an important index in the diagnose of early hypertension nephropathy. Combined with the detection of urine Alb, urineβ 2－ MG would be of a great clinical value in detecting early hypertension nephropathy and it would be useful to correctly judge the sites and the severity of the impairment.

关 键 词：高血压病 Β2-MG ALB 

分 类 号：R544.1[医药卫生—心血管疾病]