骨代谢指标在原发性骨质疏松症诊治中的临床价值  

Clinical value of bone metabolic markers in diagnosis and treatment of primary osteoporosis

作　　者：张瑾[1] 侯英萍[1] 欧阳巧洪[2] 刘加昌[2] 邓敬兰[1] 

机构地区：[1]第四军医大学西京医院核医学科,陕西西安710033 [2]解放军总医院304临床部核医学科,北京100037

出　　处：《第四军医大学学报》2005年第3期254-256,共3页Journal of the Fourth Military Medical University

摘　　要：目的:探讨骨代谢指标在原发性骨质疏松症诊治过 程中的临床价值.方法:根据不同部位的骨密度(BMP)值,将 272例中老年志愿者分为骨质疏松组(OP)和对照组,采用放 射免疫方法,对其血清骨钙素(BGP)、I型前胶原氨基端前肽 (PINP)、I型胶原交联羧基末端肽(ICTP)的含量进行测定. 结果:OP组的血清BGP值明显低于对照组,其差异具有显著 性(P<0.05);OP组的血清PINP值明显低于对照组,而血清 ICTP值明显高于对照组,其差异具有显著性(P<0.05). 结论:联合检测BGP,PINP和ICTP水平可直接反映骨胶原合 成和降解状态,对于判断老年骨质疏松症的进程以及指导骨 质疏松症的用药有着重要的临床价值.AIM: To explore the clinical values of bone metabolic markers in the diagnosis and treatment of primary osteoporosis. METHODS: Two hundred and seventy-two elderly volunteers were divided into osteoporosis (OP) group and control group according to their bone mineral density (BMD) at various skeletal sites, and serum BGP, PINP and ICTP were determined by radioimmunoassay. RESULTS: The levels of serum BGP and PINP of OP group were statistically lower than those of control group, but the level of ICTP was higher than that of control group. The difference between the two groups was of statistical significance (P<0.05). CONCLUSION: The combined determinations of serum BGP, PINP and ICTP can reflect the bone collagen metabolic conditions, which is of important clinical values for the diagnosis and treatment of primary osteoporosis.

关 键 词：原发性骨质疏松症 骨密度 骨代谢指标 

分 类 号：R68[医药卫生—骨科学]