头痛合剂的药理作用研究和临床疗效观察  

The Pharmacological and Clinical Studies of Toutong Mixture

作　　者：王有森[1] 刘佃全[1] 宋益民[2] 

机构地区：[1]山东省潍坊市人民医院,山东潍坊261041 [2]潍坊医学院,山东潍坊261041

出　　处：《中国药业》2005年第1期30-31,共2页China Pharmaceuticals

摘　　要：目的:观察头痛合剂的镇痛作用、毒性和临床疗效。方法:测定小白鼠LD50,观察其急性毒性反应;测定小白鼠扭体反应次数和痛阈,观察该制剂的镇痛作用;用正天丸作阳性对照,观察该制剂的临床疗效。结果:该制剂小白鼠的最大耐受量为400g/kg;且对家兔呼吸频率、平均动脉压和心率的作用,与给药前及生理盐水对照组比较,均无统计学差异(P>0.05);并可使小白鼠扭体次数明显减少、痛阈显著提高(P<0.05)。结论:头痛合剂有明显的镇痛效果,毒性低,是治疗头痛的有效药物。Objective:To study the pharmacological and toxic effects of Toutong mixture.Methods:LD50 was determined in mice.Torsion body and Hotplate test were used to study the analgesic effect.The clinical effects of Toutong mixture were compared with Zhengtianwan in human body.Results:The maxium tolerance dose of Toutong mixture is 400 g/kg.Toutong mixture has no effects on the MAP,heart rate and respiratory rate of rabbits.It can also decrease the number of torsion body and increase the threshold of pain in mice.Conclusion:Toutong mixture has obvious analgetic effects and low toxicity.It is a good medicine in the therapy of headache.

关 键 词：头痛合剂 药理研究 镇痛作用 毒性 临床疗效 

分 类 号：R965[医药卫生—药理学] R969.4[医药卫生—药学]