转化生长因子β1及其受体1在妊娠肝内胆汁淤积症患者胎盘绒毛组织中的表达及其意义  

Expression of transforming growth fector beta 1(TGFβ1 )and its receptor 1(TGF-βR1) in placenta of patients with intrahepatic cholestasis of pregnancy

作　　者：代鸣[1] 乔福元[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科,武汉430030

出　　处：《中国优生与遗传杂志》2005年第1期27-28,F002,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的　探讨妊娠肝内胆汁淤积症 (ICP)患者胎盘转化生长因子 β1(TGF - β1)及其受体 1(TGF - βR1)表达的变化。方法　采用S -P免疫组化方法。结果　 (1)光镜下发现ICP患者绒毛水肿、绒毛间隙狭窄 ,绒毛血管密度降低。 (2 )两组孕妇胎盘绒毛滋养层细胞均有TGF - β1的表达 ,但研究组胎盘的水平低于对照组 (P <0 .0 1)。两组孕妇胎盘绒毛滋养层细胞及血管内皮细胞均有TGF - βR1分布 ,研究组胎盘的水平低于对照组 (P <0 .0 1)。结论　ICP患者胎盘TGF - β1及TGF - βR1的低表达可能导致ICP胎儿早产、胎膜早破及宫内窘迫的发生。Objective:To explore the expression of TGFβ1 and TGF-βR1 on the placenta of introhepatic cholestasis of pregnancy (ICP). Methods:S-P immunohistochemical technique was used. Results:⑴ Placentas obtained from women with ICP had villus edema, reducing of the size of the intervillous space and depressing blood vessel density of villus under light microscopy.⑵ TGFβ1 expressed in both of the villus trophoblast cell of placenta in women with and without ICP. But its expression were lower than those of in control group (P<0.01). TGF-βR1 expressed in both of the villus trophoblast cell and blood vessel endodermis cell of placenta in women with and without ICP,its expression were lower than those of in control group (P<0.01).Conclusion:The laigh expression of placental TGFβ1 and TGF-βR1 may lead fetus abortion,Premature rupture of membranes and fetus distress in the womb.

关 键 词：转化生长因子 受体 胎盘 妊娠并发症 胆汁淤积 肝内 

分 类 号：R714.25[医药卫生—妇产科学]