阔鳞鳞毛蕨的化学成分研究  

Chemical constituents in roots of Dryopteris championii

作　　者：左丽[1] 王洪庆[1] 陈若芸[1] 

机构地区：[1]中国医学科学院中国协和医科大学药物研究所,北京100050

出　　处：《中草药》2005年第2期177-179,共3页Chinese Traditional and Herbal Drugs

摘　　要：目的研究阔鳞鳞毛蕨根的化学成分.方法利用硅胶色谱、葡聚糖凝胶色谱和制备薄层色谱进行分离纯化,根据理化性质及各种光谱技术进行结构鉴定.结果从阔鳞鳞毛蕨乙醇提取物分离得到10个化合物,分别为:绵马素-BB(aspidin-BB,Ⅰ)、绵马素-AB(aspidin-AB,Ⅱ)、aemulin-BB(Ⅲ)、methylene-bis-desaspidinol(Ⅳ)、pseudo-aspidinol B(Ⅴ)、methyl-phlor-butyrophenon(Ⅵ)、desaspidinol(Ⅶ)、hop-22(29)-ene(Ⅷ)、β-谷甾醇(Ⅸ)和(E)-3-二十九碳烯-2-酮(X).结论化合物Ⅰ～Ⅳ、Ⅵ和Ⅶ为首次从该种植物中分离得到.化合物绵马素-BB具有抗肿瘤活性.Objective To study the chemical constituents from the roots of Dryopteris championii.Methods The compounds were isolated by column chromatography with Sephadex LH-20 and silica gel and preparative thin layer chromatography.The structures of the compounds were identified by physico-chemical properties and spectral evidence.Results Ten compounds were identified as aspidin-BB (Ⅰ), aspidin-AB (Ⅱ), aemulin-BB (Ⅲ), methylene-bis-desaspidinol (Ⅳ), pseudo-aspidinol B (Ⅴ), methyl-phlor-butyrophenon (Ⅵ), desaspidinol (Ⅶ), hop-22(29)-ene (Ⅷ), β-sitosterol (Ⅸ), and (E)-3-nonacosene-2-ketone (Ⅹ).Conclusion Compound Ⅰ-Ⅳ, Ⅵ and Ⅶ are isolated from this plant for the first time.Antitumor effects of aspidin-BB are investigated.

关 键 词：阔鳞鳞毛蕨 绵马素 aemulin—BB methylene—bis—desaspidionl 

分 类 号：R284.1[医药卫生—中药学]