丹参酚酸B在水溶液中的稳定性研究  

Stability of salvianolic acid B in water solution

作　　者：岳喜典[1] 曲桂武 李桂生[2] 臧玉红[3] 池振明[1] 

机构地区：[1]中国海洋大学,山东青岛266003 [2]山东省天然药物工程技术研究中心,山东烟台264005 [3]河北承德石油高等专科学校化工系,河北承德067000

出　　处：《中草药》2005年第2期205-207,共3页Chinese Traditional and Herbal Drugs

摘　　要：目的考察不同因素对水溶液中丹参酚酸B稳定性的影响,为丹参酚酸B的生产应用提供实验依据。方法通过正交试验设计,采用HPLC法检测溶液中丹参酚酸B的含量变化考察丹参酚酸B溶液的质量浓度、pH值、温度和保温时间对丹参酚酸B稳定性的影响。结果丹参酚酸B在溶液质量浓度为1mg/mL、pH=2、温度为20℃和保存时间为1d时最稳定。结论为保持溶液中丹参酚酸B稳定性,应尽可能做到低溶液pH值、高丹参酚酸B质量浓度、低温,并且要尽量缩短溶液状态的存放时间。Objective To study the effects of different factors on the salvianolic acid B stability in water solution and to provide the experimental data for production and application of salvianolic acid B. Methods Effects of salvianolic acid B concentration, pH value, temperature, and holding period on salvianolic acid B stability in water solution were studied by the salvianolic acid B changes determined by HPLC in orthogonal design test. Results The most stable condition of salvianolic acid B is that the concentration is 1 mg/mL, pH value is 2, the temperature is 20℃ , and the holding period is one day. Conclusion Salvianolic acid B should be kept in the conditions of higher concentration, lower pH value, lower temperature, and shorter period in solution to ensure its stability.

关 键 词：丹参酚酸B 稳定性 正交试验 高效液相色谱 

分 类 号：R286.02[医药卫生—中药学]