儿童期开始年龄及其对儿童时期生长影响的纵向研究  

Longitudinal study on the age at childhood onset in children from Shanghai and its effects on child growth

作　　者：徐秀[1] 郭志平[1] 王卫平[1] Karlberg J 

机构地区：[1]复旦大学附属儿科医院儿童保健科 [2]香港大学玛丽医院儿科系

出　　处：《中华儿科杂志》2004年第12期902-907,共6页Chinese Journal of Pediatrics

摘　　要：目的　应用婴儿 儿童 青春期 (ICP)生长模型研究儿童期开始年龄 (ACO)并探讨其对儿童时期生长的影响。方法　选择自出生纵向随访至 6岁的小儿共 16 2 3名。根据计算机绘制的每个小儿身长及其身长速率曲线对应ICP生长曲线图来判断ACO值。结果　男、女孩的平均ACO值分别为 11 2个月和 10 7个月。女孩显著早于男孩 (P <0 0 5 )。ACO值对儿童后期的生长有显著的作用 ,儿童期开始年龄延迟 1个月 ,到 5岁时其身高男孩降低 0 4cm、女孩降低 0 5 6cm。对ACO值的影响因素进行多元回归分析发现 ,性别、6月龄时身长和父母亲平均身高与ACO值均有显著关系 (P <0 0 5 )。对儿童期开始年龄和父母亲平均身高作线性相关分析发现 ,父母亲平均身高低于均数 2个标准差的男、女孩其儿童期开始年龄要比父母亲平均身高高于均数 2个标准差的男、女孩分别晚 1 5个月和 1 3个月。结论　应用ICP生长模型同样适合我国儿童体格生长的研究 。Objective The infancy-childhood-puberty (ICP) growth model divides human growth into three additive and partly superimposed phases: infancy, childhood, and puberty reflecting the endocrinology of the growth process. The childhood phase of the ICP model has been assumed to start during the second half-year of life and slowly decelerates, although it continues into puberty until growth ceases. This phase has been taken to mirror the effect of growth hormone (GH). The age at onset of the phase of growth, normally occurring between 6 and 12 months of age is recognized to be an important time event at postnatal human growth. The aims of this study were to study the age at childhood onset in Shanghai children and its effect on child growth, and to compare these results with the results obtained from Swedish longitudinal studies. Methods The study population consisted of 1 720 children born between January 1, 1980, and December 31, 1990 in Fenglin Community, Shanghai, who got a continual monitoring at the clinic from birth to six years of age. The age at onset of the ‘childhood phase’ of growth was determined individually, in units of one month, by visual inspection of the data contained within the individual, computer-generated, ICP-based growth chart for both length and length velocity. T tests, χ 2 tests and multiple linear regression analyses were used in data analysis. Results There was a significant ( P <0.05) difference in the distribution of the age at onset of the childhood phase of growth between Shanghai and Swedish populations. The mean age of the infants at onset of the ‘childhood phase’ of growth was 11.2 months in boys and 10.7 months in girls. Compared to their Swedish counterparts, these means occurred 1.3 months later in boys and 1.4 months later in girls. Both age at onset of the ‘childhood phase’ of growth and length at six months of age significantly ( P <0.05) contributed to the attained height from 12 months of age onward; one month delay in the onset of the ‘childhood phase’

关 键 词：儿童期 年龄 身高 女孩 父母亲 身长 纵向研究 生长模型 生长影响 月龄 

分 类 号：R179[医药卫生—妇幼卫生保健] R749[医药卫生—公共卫生与预防医学]