PMBP-苯甲酰腙过渡金属配合物的合成与生物活性研究  

Studies on synthesis and antioxidative activity of transitional complexes of PMBP-benzoyl hydrazone

作　　者：杨正银[1] 郑金福[1] 杨春莉[1] 

机构地区：[1]兰州大学化学化工学院,甘肃兰州730000

出　　处：《兰州大学学报（自然科学版）》2004年第6期51-54,共4页Journal of Lanzhou University(Natural Sciences)

基　　金：国家自然科学基金资助项目(20435047)

摘　　要：通过1-苯基-3-甲基-4-苯甲酰基-5-羟基吡唑缩苯甲酰腙(H2PBB)和过渡金属乙酸盐反应,制备了组成为M(PBB)2·nH2O(M=Mn,Cu时n=0;M=Fe,Co,Ni,Zn时n=1)的6个过渡金属配合物,利用元素分析,IR,UV,TG-DTA,NMR等手段对配体和配合物进行了结构表征.生物活性测定结果表明PMBP-苯甲酰腙过渡金属配合物具有一定的抗脂质过氧化活性.The 1-phenyl-3-methyl-5-hydroxy-4-pyrazolyl phenyl ketone benzoyl hydrazone(H2PBB) was prepared by condensation of 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone with benzoyl hydrazine. Six complexes of transition with H2PBB have been synthesized and characterized on the basis of elemental analyses, IR, UV, 1H NMR spectra and thermal analyses. The results show that the transition complexes of F2PBB have antioxidative acivity to certain extent.

关 键 词：过渡金属配合物 腙 生物活性 

分 类 号：O611.45[理学—无机化学]