2,4-二氟苯胺基丙酸酯的合成和生物活性研究  

Synthesis and Bioactivity of N-Acyl-N-(2,4-Difluoroanilino)Propionates

作　　者：王鸣华[1] 章维华[1] 蒋木庚[1] 

机构地区：[1]南京农业大学理学院,南京210095

出　　处：《农药》2005年第1期13-15,共3页Agrochemicals

摘　　要：采用重氮化法制备了2,4-二氟苯胺,然后与α-溴丙酸酯反应合成N-(2,4-三氟苯胺基)丙酸酯,再与7种不同的酰氯缩合制备N-酰基-N-(2,4-二氟苯胺基)丙酸酯。其生物活性试验表明,-酰基-N-(2,4-二氟苯胺基)N丙酸酯10mg/L浓度下对小麦纹枯病抑制率为74.0%￣84.4%,对瓜类灰霉病的抑制率为93.6%￣98.9%。difluoroaniline was prepared by diazotization-fluoration, followed by condensation with α-bromopropionate and seven acylchlorides to get N-acyl-N-(2,4-difluoroanilino)propionates. Bioassay tests of these compounds at 10 mg/L indicated that activity against Rhizoctonia cerealis was 74.0 to 84.4% and activity against Botrytis cinerea was 93.6 to 98.9%.

关 键 词：2 4-二氟苯胺 化学合成 2 4-二氟苯胺基丙酸酯 生物活性 

分 类 号：TQ455.4[化学工程—农药化工]