空腹血糖增高与糖负荷后血糖增高临床特征的分析  

Analysis of the clincal characteristics of increased fasting glucose and increased postchallenge glucose

作　　者：李蓉[1] 张素华[1] 任伟[1] 龚莉琳[1] 李革[2] 李启富[1] 卢仙娥[2] 汪志红[1] 陈静[1] 包柄楠[1] 杜娟[1] 王继旺[1] 吴豪杰[1] 白晓苏[1] 邓吉容[1] 

机构地区：[1]重庆医科大学附属第一医院内分泌科,400016 [2]重庆医科大学流行病学教研室,400016

出　　处：《重庆医学》2005年第1期10-12,15,共4页Chongqing medicine

基　　金：重庆市卫生局医学科学基金资助 (2 0 0 0 - 2 0 2 7)

摘　　要：目的　比较空腹血糖增高和糖负荷后血糖增高的临床特征。方法　采用横断面分析的方法 ,对重庆地区 2 1～ 89岁人群进行了调查 ,根据空腹血糖和糖负荷后 2h血糖 ,将调查人群分为正常糖代谢 (NGT)、单纯空腹血糖受损 (iIFG)、单纯糖耐量低减 (iIGT)、联合糖调节受损 (IFG/IGT)、单纯空腹高血糖 (IFH)、单纯负荷后高血糖 (IPH)和联合血糖增高 (IFH/IPH) 7组 ,分别比较各组的糖脂代谢状况。结果　iIGT和IPH分别是IGR和DM的主要类型 ,分别占IGR的 6 1.4 %和初发DM的 6 0 .5 %。i IFG、iIGT、IFG/IGT、IPH、IFH/IPH各组的检出率均随着年龄的增加而有增高趋势。IGR人群中 ,IFG/IGT的SBP更高 ,脂代谢异常更明显 ,iIFG与iIGT则具有相似的代谢特征 ;DM患者中 ,FH组代谢紊乱重于IPH组。结论　iIGT和IPH分别是IGR和DM的主要类型 ,测定餐后 2h血糖有助于筛查到iIGT和IPH。Objective To campare the clincal characteristcs of increased fasting glucose and increased postchallenge glucose. Methods A cross-sectional analysis of glucose and lipid metabolism was conducted in Chongqing adults aged 21 to 89 years. According to fasting plasma glucose(FPG) and 2h plasma glucose(2hPG),the subjects were divided into 7 groups: normal glucose tolerance(NGT), isolated impaired fasting glucose(iIFG), isolated impaired glucose tolerance(iIGT),combined IFG and IGT(IFG/IGT),isolated fasting hyperglycemia (IFH) ,isolated postchallenge hyperglycemia (IPH), combined IFH and IPH (IFH/IPH).The prevalence and metabolic features of the above subcategories were analyzed. Results iIGT was the most common subsection in the impaired glucose regulation (IGR) group (61.4%),and IPH was the most common subsection in the diabetes patients ( 60.5 %).With the increasing of age, the frequencies of NGT, iIFG, iIGT, IFG/IGT, IPH, IFH/IPH increased. Compared with iIFG and iIGT groups, IFG/IGT group had higher systolic pressure, more serious dyslipidemia. While iIFG and iIGT had identical metabolic characteristcs. In diabetic patients, compared with IPH group, fasting hyperglycemia(FH)had more serious metabolism disorder.Conclusion iIGT and IPH are the most common subsections in the IGR group and DM group respectively. The test of OGTT is help ful to screen IGT and IPH.

关 键 词：空腹血糖受损 糖耐量低减 单纯负荷后高血糖 

分 类 号：R587.1[医药卫生—内分泌] R446.112[医药卫生—内科学]