LN和TN在正常子宫内膜与子宫内膜异位症异位内膜中的表达及意义  

The expression and significance of laminin and tenascin in the human endometrium and endometriosis

作　　者：于晓伟[1] 岳瑛[1] 宣兆艳[2] 卢英强[2] 车绍捷 杨玉兰[1] 李林藜[1] 

机构地区：[1]吉林大学第一医院妇产科,吉林长春130021 [2]吉林大学基础医学院法医教研室 [3]兴安盟妇幼保健所

出　　处：《中国实验诊断学》2004年第6期585-587,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的为了研究细胞外基质层粘连蛋白(LN)与肌腱蛋白(TN)在正常子宫内膜及子宫内膜异位症(内异症)异位内膜上的表达,探讨两者与内异症发生的关系。方法应用免疫组化方法分别检测正常子宫内膜及内异症异位内膜病理蜡块标本LN及TN表达水平。结果LN在内异症异位内膜和正常子宫内膜组织的基底膜及细胞外基质(ECM)中表达差异不显著;TN在内异症异位内膜和正常子宫内膜组织的腺上皮及ECM中表达差异有显著性。结论LN的表达与内异症的发生无关,不能作为内异症的一种预测指标。TN在内异症异位内膜及正常子宫内膜中的细胞外基质中表达差异显著,对内异症的发生可能起重要作用。Objective To compare the localization of adhesion proteins laminin and tenascin in endometrium and endometriosis. Methods The specimens of twenty-two cases with endometriosis were studied retrospectively by S-P immunohistohemical stainings. For controls, thirty samples of normal endometrium were also analysed. Results The positive expression of LN in endometriosis did not show observable difference from the normal. The positive of TN in endometriosis was significantly higher than that in the normal endometriosis. Conclusion LN may not be an effective indicator in endometriosis. In the progression and development of endometriiosis, TN may play an important role.

关 键 词：子宫内膜异位症 层粘连蛋白 肌腱蛋白 

分 类 号：R711.71[医药卫生—妇产科学]