伏隔核与腹侧被盖区毁损对药物诱导大鼠吗啡觅药行为的影响  

Lesion effects of nucleus accumbens and ventral tegmental area on drug priming-induced reactivation of extinguished conditioned place preference in rats

作　　者：梁秦川[1] 高国栋[2] 

机构地区：[1]第四军医大学唐都医院神经外科,陕西西安710038 [2]第四军医大学全军神经科学研究所,陕西西安710033

出　　处：《第四军医大学学报》2005年第2期122-124,共3页Journal of the Fourth Military Medical University

摘　　要：目的:研究定向毁损伏隔核(nucleusaccumbens, NAc)与腹侧被盖区(ventraltegmentalarea,VTA)对药物诱导 戒断大鼠吗啡觅药行为的影响,分析NAc和VTA在大鼠成瘾 行为中的作用.方法:雄性SD大鼠通过吗啡强化形成条件性 位置偏爱后,使用直流电分别毁损NAc与VTA.15d后给予 sc吗啡诱导大鼠恢复位置偏爱行为,测量并比较毁损组与对 照组的位置偏爱得分.结果:NAc毁损组和与VTA毁损组大 鼠在注射吗啡诱导下未恢复对吗啡的条件性位置偏爱[NAc 毁损组(471±52)s,NAc对照组(673±53)s;VTA毁损组 (482±49)s,VTA对照组(700±46)s].结论:毁损NAc和 VTA能阻断注射吗啡诱导戒断大鼠恢复觅药行为.在成瘾药 物诱导戒断动物觅药行为中,NAc和VTA起重要作用.AIM: To examine the possible role of nucleus accumbens (NAc) and ventral tegmental area (VTA) in drug priming-induced reactivation of extinguished conditioned place preference (CPP). METHODS: After the rats were successfully trained with morphine (10 mg/kg, sc.) by a CPP paradigm, NAc and VTA were lesioned with a DC current passing through the location. After a 15-day Abstinence period, drug priming (morphine 1 mg/kg, sc.) was given and the place preference score was recorded. RESULTS: Drug priming reactivated the place preference in sham lesion rats. However, the effect of drug priming-induced reactivation of extinguished CPP could be completely abolished by lesion of NAc and VTA. CONCLUSION: These results indicate that NAc and VTA play an important role in drug priming-induced reactivation of extinguished CPP.

关 键 词：吗啡 复吸 伏核 腹侧被盖区 条件性位置偏爱 

分 类 号：Q189[生物学—神经生物学]