纳米级羟基磷灰石梯度涂层植入体骨结合的研究  

Experimental Study on the Osteointegration of Nanophase Hydroxyapatite Biograde-coated Implants

作　　者：谭延斌[1] 王毅[1] 杨庆铭[1] 邓廉夫[1] 肖德常[1] 冯伟[1] 曾绍先[2] 

机构地区：[1]上海市伤骨科研究所(上海第二医科大学附属瑞金医院骨科),200025 [2]中国科学院上海硅酸盐研究所

出　　处：《中国骨与关节损伤杂志》2005年第1期38-40,共3页Chinese Journal of Bone and Joint Injury

基　　金：上海市纳米专项资助项目 (项目编号 0 1 4 4nm0 64)

摘　　要：目的　评价纳米级羟基磷灰石梯度涂层 (HAP)植入体 -骨界面骨结合情况。方法　在Beagle犬股骨内植入纳米级HAP梯度涂层栓、普通级HAP涂层栓和钛合金 (Ti- 6AL - 4V)栓 ,在 4、 8、 12周比较X线结果和植入体 -骨界面剪切强度。结果　各时间点纳米级HAP涂层组和普通HAP梯度涂层组的X线结果相当 ,植入体 -骨界面剪切强度均优于钛合金组和钛合金组。结论　纳米级HAP梯度涂层植入体与骨有很好的结合力 ,能够加速骨质的愈合。Objective To appraise the osteointegration between the nanophase hydroxyapatite biograde-coated implants and host bone.Methods Nanophase hydroxyapatite biograde-coated implants,hydroxyapatite biograde-coated implants and noncoated Ti-6AL-4V implants were inserted into both femoral of Beagle canines,X-ray and biomechanical test were performed at 4,8 and 12 weeks.Results The X-ray images of nanophase hydroxyapatite biograde-coated implants were homological with that of hydroxyapatite biograde-coated implants,and biomechanical tests of nanophase hydroxyapatite biograde-coated implants were better than that of hydroxyapatite biograde-coated implants and Ti-6AL-4V implants at 4,8 and 12 weeks.Conclusion The osteointegration between nanophase hydroxyapatite biograde-coated implants and host bone are excellent and the stability of coated implants can be achieved within short period.

关 键 词：纳米级 羟基磷灰石 梯度涂层 体-骨界面植入 骨结合 全髋关节置换术 

分 类 号：R687.4[医药卫生—骨科学] R318[医药卫生—外科学]