一种新型的可生物降解的热敏凝胶微粒的制备  

Preparation of a Novel Thermosensitive and Biodegradable Microgel Particles

作　　者：朱文[1] 张颖[1] 王标兵[1] 丁建东[1] 

机构地区：[1]复旦大学高分子科学系

出　　处：《高等学校化学学报》2005年第2期373-375,共3页Chemical Journal of Chinese Universities

基　　金：国家"八六三"计划项目(批准号:2004AA215170);国家自然科学基金(批准号:20174006;20221402;20374015;30271293);高等学校青年教师教学和科研奖励基金;上海市科技发展基金;国家重点基础研究"九七三"项目(批准号:G1999054306-03).

摘　　要：A novel biodegradable and thermosensitive microgel particle was prepared via suspension polymerization of a well-designed biodegradable macromonomer. The macromonomer is composed of amphiphilic block copolymer PEO-PPO-PEO, oligo(ester) and acryloyl end groups. Ammonium persulfate was employed as the initiator and N,N,N′,N′-tetramethylethylene-diamine as the accelerator. The resultant hydrogel particles were confirmed to be reversely thermosensitive as well as biodegradable.A novel biodegradable and thermosensitive microgel particle was prepared via suspension polymerization of a well-designed biodegradable macromonomer. The macromonomer is composed of amphiphilic block copolymer PEO-PPO-PEO, oligo(ester) and acryloyl end groups. Ammonium persulfate was employed as the initiator and N,N,N′,N′-tetramethylethylene-diamine as the accelerator. The resultant hydrogel particles were confirmed to be reversely thermosensitive as well as biodegradable.

关 键 词：水凝胶 热敏性 可降解 微粒 大分子单体 

分 类 号：O631[理学—高分子化学]