瘦素与2型糖尿病患者微血管病变关系的探讨  

Study on the Relationship Between Serum Levels of Leptin and Microangiopathy in Patients with Type 2 Diabetes

作　　者：曹慧玲[1] 郭冬梅[1] 

机构地区：[1]大连医科大学附属第二医院核医学科,116027

出　　处：《放射免疫学杂志》2004年第6期419-421,共3页Journal of Radioimmanology

摘　　要：目的 :探讨瘦素与 2型糖尿病患者微血管病变的关系。方法 :对照组、糖尿病无微血管病变组及糖尿病微血管病变组各 30例 ,其中糖尿病微血管病变组包括糖尿病肾病 2 5例 ,糖尿病视网膜病变 12例 ,同时合并DN与DR者 7例。检测血清瘦素、胰岛素及血糖浓度 ,分析瘦素水平与其它指标的相关性。结果 :对照组、无微血管病变组及微血管病变组血清瘦素浓度分别为 (7 2 0± 2 11) μl/L、(7 95± 3 78) μg/L及 (10 2 6± 4 37)μg/L ,糖尿病微血管病变组显著高于无微血管病变组 (t=2 .18,P <0 0 5 )及对照组 (t=2 .71,P <0 0 1) ,而后两者间无显著差异 ;瘦素浓度与体重指数、胰岛素呈正相关 (r =0 .2 9,P <0 0 5 ;r =0 .34,P <0 .0 1)。结论 :糖尿病微血管病变组血清瘦素浓度升高 ,瘦素与糖尿病微血管病变的发病密切相关。Objective To evaluate the relationship between serum levels of leptin and microangiopathy in patients with type 2 diabetes. Methods Fasting serum leptin (with RIA), insulin (with RIA) and fasting blood glucose (with oxidase method) levels were measured in 30 controls, 30 diabetic patients without microangiopathy and 30 patients with diabetic microangiopathy. Correlations between levels of serum leptin and other parameters were analyzed. Results The levels of serum leptin in controls, diabetic patients without microagngiopathy and patients with diabetic microangiopathy were (7.20±2.11)μg/L, (7.95±3.78)μg/L and (10.26±4.37)μg/L respectively. The patients with diabetic microangiopathy had higher serum leptin levels than those in the diabetic patients without microangiopathy (t=2.18, P<0.05) and controls (t=2.71, P<0.01), while the serum leptin levels in diabetic patients without micoangiopathy were not significantly different from those in controls. The serum reptin levels were positively correlated with BMI and FINS (r=0.29, P<0.05; r=0.34, P<0.01). Conclusion Serum leptin levels were elevated in patients with diabetic microangiopathy and were closely related with the development of diabetic microangiopathy.

关 键 词：糖尿病微血管病变 血清瘦素浓度 对照组 患者 2型糖尿病 胰岛素 瘦素水平 

分 类 号：R587[医药卫生—内分泌] R544.1[医药卫生—内科学]