S-100B蛋白在颅脑损伤诊断分型中的临床意义  

Clinical Significance of Serum S-100B Protein Levels in the Grading of Brain Injury

作　　者：郭红梅[1] 郭兵[1] 胡殿雷[2] 王齐[3] 

机构地区：[1]江苏省徐州市第三人民医院检验科,221005 [2]江苏省徐州市第三人民医院神经外科,221005 [3]江苏省徐州市第三人民医院,江苏大学实习生221005

出　　处：《放射免疫学杂志》2004年第6期468-469,共2页Journal of Radioimmanology

摘　　要：目的 :通过测定血清S - 10 0B蛋白浓度 ,探讨其在颅脑损伤诊断分型中的意义。方法 :80例颅脑损伤患者 ,根据格拉斯哥昏迷评分 (GCS评分 )分为轻型、中型、重型三组 ,伤后早期 (<6h)用酶联免疫吸附法测定血清S - 10 0B蛋白浓度 ,并动态检测 (3～ 7)d。结果 :各组血清S - 10 0B蛋白平均浓度 ,轻型组 :(0 35± 0 13)μg/L ;中型组 :(0 77± 0 2 0 ) μg/L ;重型组 :(1 12± 0 30 ) μg/L。三组比较得出P <0 0 0 5 ,S - 10 0B蛋白含量与GCS评分成负相关。结论 :血清S - 10 0B蛋白浓度是判断颅脑损伤诊断分型较为理想的生物学指标。Objective To investigate the clinical significance of determination of serum S-100B protein levels in the grading of brain injury. Methods Eighty patients with brain injury were classified in to three grades according to the Glascow score: 13～15, minor grade n=30; 9～12, moderate, n=25; 3～8, severe n=25. Serum S-100B protein levels were measured with ELISA in these patients 6h after the injury and daily thereafter for 3～7 days. Results The mean concentrations of serum S-100B protein in these patients were as followings; minor grade, 0.35±0.13μg/L; moderate grade, 0.77±0.20μg/L; severe grade 1.12±0.30μg/L(differences among them being significant, P<0.005). The S-100B protein levels were negatively correlated with the Glascow score. Conclusion Serum concentrations of S-100B protein is an ideal screening bio-marker for the severity of brain injury.

关 键 词：S-100B蛋白 颅脑损伤 诊断分型 血清 GCS评分 临床意义 重型 负相关 生物学指标 

分 类 号：R651.15[医药卫生—外科学] R743[医药卫生—临床医学]