轮状病毒感染成年小鼠的研究  

Infection of Adult Mouse by Rotavirus

作　　者：李嘉琦[1] 刘晓[1] 熊新宇[1] 陈瑜娜[1] 陈元鼎[1] 

机构地区：[1]中国医学科学院中国协和医科大学医学生物学研究所,昆明650118

出　　处：《中国实验动物学报》2004年第4期239-241,共3页Acta Laboratorium Animalis Scientia Sinica

基　　金：云南省自然科学基金资助项目(编号:2001C0073M)。

摘　　要：目的研究成年昆明种小鼠对实验感染人轮状病毒(rotavirus,RV)的敏感性。方法在实验条件下,用A组人Wa和恒河猴SA11株RV感染成年昆明种小鼠,观察小鼠的临床反应和排毒情况。结果成年昆明种小鼠感染Wa和SA11RV第二天后出现明显的临床腹泻症状,第四天达到高峰;至少在感染后连续6天的动物大便中可检测到较高滴度的RV抗原。结论成年昆明种小鼠对RV感染有很高的敏感性,可做为动物模型,在RV感染的药物治疗效果评价和疫苗保护性效果评价中具有重要价值。Objective To determine susceptibility of adult strain Kunming mouse to rotavirus (RV) infection. Methods Adult strain Kunming mice were experimentally perorally infected by group A rotavirus, human Wa and rhesus SA11. Clinical response was observed and RV antigen in animal stools was detected. Results Apparent diarrhea was observed in mice 2 days post infection and peaked at 4 days; RV antigen could be detected in stool samples collected from infected mice at least from the second to sixth day post infection. Conclusion\ Kunming mouse is susceptible to RV infection and could be used as an adult animal model for evaluation of efficacy of medicinal treatment and vaccine protection to RV infection.

关 键 词：成年小鼠 轮状病毒感染 RV 成年 SA 大便 感染后 腹泻症状 实验感染 高滴度 

分 类 号：Q958[生物学—动物学] R512.5[医药卫生—内科学]