阿魏酸钠拮抗豚鼠哮喘的药理机制研究  

Study on the Pharmacological Mechanism of Sodium Ferulate for Anti-ast hmatic Eff ect in Guinea Pigs

作　　者：孙云[1] 徐峰[1] 张洪泉[1] 

机构地区：[1]扬州大学医学院,江苏225001

出　　处：《中国中西医结合杂志》2004年第12期1103-1105,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：江苏省科学委员会基金项目 (No .BK981 3531 3)

摘　　要：目的研究阿魏酸钠对豚鼠哮喘的作用及其机制。方法致敏豚鼠给予 2 5、5 0、10 0mg/kg 3种不同浓度的阿魏酸钠 ,并用卵白蛋白引喘豚鼠 ,检测引喘后 8天豚鼠血清与肺组织中的内皮素 1(ET)、一氧化氮 (NO)以及血液、肺泡灌洗液 (BALF)中嗜酸性粒细胞 (EOS)的变化情况。结果阿魏酸钠可明显降低血清和肺组织中的ET含量 (P <0 0 5 ,P <0 0 1) ,升高血清和肺组织中NO浓度 (P <0 0 5 ,P <0 0 1) ,减少血液和肺泡灌洗液中EOS的数量 (P <0 0 5 ,P <0 0 1) ;高剂量组作用较强。结论阿魏酸钠可增加体内NO浓度 ,降低ET含量、减轻EOS浸润 ,拮抗豚鼠哮喘。ObjectiveTo study the anti-asthmatic effect o f sodium ferulate (SF) and its mechanism in guinea pig asthmatic model. MethodsGuinea pigs were sens itized with ovalbumin as animal asthmatic model and treated with 3 different con centration of SF for 8 days. Levels of endothelin (ET) and nitric oxide (NO) in blood and lung tissue, and eo sinophil (EOS) in blood and bronchoalveolar lavage fluid (BLAF) was counted at t he end of trial. ResultsSF could significantly lower th e ET content and incre ase the NO concentration in serum and lung tissue, reduce the number of EOS in b lood and BLAF (P<0.05, P<0.01). Stronger eff ect was showed in the high dose group. ConclusionMechanism of anti-asthmatic action of SF might be to increase NO concent ration, lower ET content, alleviate EOS infiltration.

关 键 词：阿魏酸钠 豚鼠 哮喘 肺组织 ET 血清 NO浓度 结论 目的 拮抗 

分 类 号：R285[医药卫生—中药学]